Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 16/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
| ▸ | DRD5 | P21918 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4590221 | 0.87 | KCNA5 (0.40) | HRH3 | |
| SCHEMBL4590572 | 0.87 | HRH3 (0.44) | HRH3 | |
| SCHEMBL4591346 | 0.84 | HRH3 (0.42) | HRH3 | |
| SCHEMBL4590727 | 0.84 | HRH3 (0.42) | HRH3 | |
| SCHEMBL4590050 | 0.84 | FGFR1 (0.60) | HRH3FGFR1SRC | |
| SCHEMBL4590576 | 0.81 | AVPR1B (0.45) | HRH3 | |
| SCHEMBL4591158 | 0.79 | HRH3 (0.46) | HRH3SLC6A4HTR1ADRD2DRD1 | |
| SCHEMBL4590224 | 0.78 | KCNA5 (0.40) | HRH3DRD2 | |
| SCHEMBL4590225 | 0.78 | KCNA5 (0.40) | HRH3DRD2 | |
| SCHEMBL4590678 | 0.77 | HRH3 (0.35) | HRH3FGFR1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008107322-A1 | INDOLE, BENZIMIDAZOLE OR BENZOTRIAZOLE DERIVATIVES INCLUDING A PIPERIDINE OR PIPERAZINE CORE AS ANTI-NEOPLASIC AGENTS OR CELL PROLIFERATION INHIBITORS | CEREP (FR) | 2008-09-12 | — | — | WO | disclosed |