Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 5/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4590225 | 0.88 | KCNA5 (0.40) | KCNA5HRH3DRD2DRD4HPGD | |
| SCHEMBL4589926 | 0.87 | FGFR1 (0.49) | KCNA5HRH3DRD2DRD4 | |
| SCHEMBL4590221 | 0.86 | KCNA5 (0.40) | KCNA5HRH3HPGDL3MBTL1MEN1 | |
| SCHEMBL4590576 | 0.86 | AVPR1B (0.45) | KCNA5HRH3MEN1KMT2A | |
| SCHEMBL4590572 | 0.83 | HRH3 (0.44) | HRH3HPGDL3MBTL1MEN1KMT2A | |
| SCHEMBL4590553 | 0.83 | KCNA5 (0.41) | KCNA5HRH3DRD2DRD4MEN1 | |
| SCHEMBL4590727 | 0.81 | HRH3 (0.42) | HRH3HPGDL3MBTL1MEN1KMT2A | |
| SCHEMBL4591346 | 0.79 | HRH3 (0.42) | HRH3MEN1KMT2A | |
| SCHEMBL4590774 | 0.78 | HRH3 (0.45) | HRH3DRD2 | |
| SCHEMBL4589930 | 0.74 | FGFR1 (0.49) | KCNA5HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008107322-A1 | INDOLE, BENZIMIDAZOLE OR BENZOTRIAZOLE DERIVATIVES INCLUDING A PIPERIDINE OR PIPERAZINE CORE AS ANTI-NEOPLASIC AGENTS OR CELL PROLIFERATION INHIBITORS | CEREP (FR) | 2008-09-12 | — | — | WO | claimed |
| WO-2008107322-A1 | INDOLE, BENZIMIDAZOLE OR BENZOTRIAZOLE DERIVATIVES INCLUDING A PIPERIDINE OR PIPERAZINE CORE AS ANTI-NEOPLASIC AGENTS OR CELL PROLIFERATION INHIBITORS | CEREP (FR) | 2008-09-12 | — | — | WO | disclosed |