Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | ALAD | P13716 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.37 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | AHR | P35869 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | IKBKB | O14920 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4598589 | 0.84 | PGR (0.42) | PGRALADALDH1A1RAB9AMEN1 | |
| SCHEMBL2774954 | 0.82 | CNR1 (0.44) | CNR1ALADALDH1A1RAB9AMEN1 | |
| SCHEMBL29280044 | 0.82 | BRD4 (0.45) | CNR1PGRMAPTIKBKBCYP1A2 | |
| SCHEMBL10706711 | 0.78 | HSD17B1 (0.56) | MEN1KMT2ACYP3A4CYP2C9HSD17B1 | |
| SCHEMBL4590721 | 0.78 | MAPK14 (0.50) | PGRALDH1A1RAB9AMEN1MAPT | |
| SCHEMBL3907230 | 0.77 | AR (0.44) | CNR1PGRALDH1A1RAB9AMAPT | |
| SCHEMBL28245811 | 0.77 | HSD17B1 (0.46) | CNR1ALADALDH1A1MEN1POLB | |
| SCHEMBL27270524 | 0.77 | CNR1 (0.41) | CNR1ALADALDH1A1RAB9AMEN1 | |
| SCHEMBL10583935 | 0.77 | IKBKB (0.46) | CNR1ALADALDH1A1RAB9AMEN1 | |
| SCHEMBL4200384 | 0.77 | CNR1 (0.41) | CNR1ALADALDH1A1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1909775-A2 | FORMULATION OF RADIOPROTECTIVE ALPHA, BETA UNSATURATED ARYL SULFONES | Onconova Therapeutics, Inc. (US) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007016201-A2 | FORMULATION OF RADIOPROTECTIVE α, β UNSATURATED ARYL SULFONES | ONCONOVA THERAPEUTICS, INC. (US) | 2007-02-08 | — | — | WO | disclosed |