⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3127322 | 0.67 | — | — | |
| SCHEMBL4591232 | 0.63 | — | — | |
| SCHEMBL5710530 | 0.60 | — | — | |
| SCHEMBL10482970 | 0.57 | — | — | |
| SCHEMBL1140200 | 0.57 | — | — | |
| SCHEMBL4589598 | 0.56 | — | — | |
| SCHEMBL15324575 | 0.55 | — | — | |
| SCHEMBL19820369 | 0.53 | — | — | |
| SCHEMBL10520401 | 0.53 | GABRA1 (0.33) | — | |
| SCHEMBL1465555 | 0.53 | CCNB2 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2964209-B1 | CO-ADMINISTRATION OF STEROIDS AND ZOLEDRONIC ACID TO PREVENT AND TREAT OSTEOARTHRITIS | LEVOLTA PHARMACEUTICALS INC (US) | 2021-10-27 | — | — | EP | disclosed |
| US-9737553-B2 | Co-administration of steroids and zoledronic acid to prevent and treat osteoarthritis | LEVOLTA PHARMACEUTICALS, INC. (US) | 2017-08-22 | — | — | US | disclosed |
| EP-2964209-A1 | CO-ADMINISTRATION OF STEROIDS AND ZOLEDRONIC ACID TO PREVENT AND TREAT OSTEOARTHRITIS | Levolta Pharmaceuticals, Inc. (US) | 2016-01-13 | — | — | EP | disclosed |
| US-20150031649-A1 | CO-ADMINISTRATION OF STEROIDS AND ZOLEDRONIC ACID TO PREVENT AND TREAT OSTEOARTHRITIS | VOLTARRA PHARMACEUTICALS, INC. (US) | 2015-01-29 | — | — | US | disclosed |
| US-8859530-B2 | Co-administration of steroids and zoledronic acid to prevent and treat osteoarthritis | VOLTARRA PHARMACEUTICALS, INC. (US) | 2014-10-14 | — | — | US | disclosed |
| WO-2014138712-A1 | CO-ADMINISTRATION OF STEROIDS AND ZOLEDRONIC ACID TO PREVENT AND TREAT OSTEOARTHRITIS | VOLTARRA PHARMACEUTICALS, INC. (US) | 2014-09-12 | — | — | WO | disclosed |
| US-20140256682-A1 | CO-ADMINISTRATION OF STEROIDS AND ZOLEDRONIC ACID TO PREVENT AND TREAT OSTEOARTHRITIS | LEVOLTA PHARMACEUTICALS, INC. | 2014-09-11 | — | — | US | disclosed |
| US-20080286352-A1 | Liposome Compositions | NOVARTIS AG (CH) | 2008-11-20 | — | — | US | disclosed |
| US-4939130-A | Substituted alkanediphosphonic acids and pharmaceutical use | CIBA-GEIGY CORPORATION (US) | 1990-07-03 | — | — | US | disclosed |