⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4591184 | 0.63 | — | — | |
| SCHEMBL4589598 | 0.62 | — | — | |
| SCHEMBL278205 | 0.59 | — | — | |
| SCHEMBL3127322 | 0.59 | — | — | |
| SCHEMBL5710530 | 0.56 | — | — | |
| SCHEMBL10520401 | 0.54 | GABRA1 (0.33) | — | |
| SCHEMBL1465555 | 0.54 | CCNB2 (0.30) | — | |
| SCHEMBL19820369 | 0.54 | — | — | |
| SCHEMBL5831274 | 0.54 | ALDH1A1 (0.33) | — | |
| SCHEMBL11119104 | 0.54 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10316035-B2 | Triazolopyridine inhibitors of myeloperoxidase | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-06-11 | — | — | US | claimed |
| US-20180244671-A1 | TRIAZOLOPYRIDINE INHIBITORS OF MYELOPEROXIDASE | BRISTOL-MEYERS SQUIBB COMPANY (US) | 2018-08-30 | — | — | US | claimed |
| WO-2017040450-A1 | TRIAZOLOPYRIDINE INHIBITORS OF MYELOPEROXIDASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-03-09 | — | — | WO | claimed |
| US-6770667-B1 | N-((IMIDAZOLYL)-PHENYL)-FLUORENE-1-CARBOXAMIDE DERIVATIVES; 5-HYDROXYTRYPTAMINE (5-HT) ANTAGONISTS; PSYCHOLOGICAL, NERVOUS SYSTEM, EATING, BRAIN AND SLEEP DISORDERS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-08-03 | — | — | US | claimed |
| EP-0582829-B1 | 9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines as antibiotic agents | AMERICAN CYANAMID CO (US) | 2001-09-12 | — | — | EP | claimed |
| US-5550233-A | AUTOIMMUNE DISEASES; PREVENTION OF TRANSPLANT REJECTION | MERCK & CO., INC. (US) | 1996-08-27 | — | — | US | claimed |
| US-5495031-A | Process for the production of 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines | AMERICAN CYANAMID COMPANY (US) | 1996-02-27 | — | — | US | claimed |
| US-5442059-A | Antibiotics for mammalian and veterninary diseases | AMERICAN CYANAMID COMPANY (US) | 1995-08-15 | — | — | US | claimed |
| EP-0361317-B1 | Pyridoindole derivatives and processes for preparation thereof | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-04-05 | — | — | EP | claimed |
| CN-1087626-A | The glycyl that novel 7-(replacement)-8-(replacement)-9-[(replaces) amido]-6-demethyl-6-deoxidation tsiklomitsin | AMERICAN CYANAMID CO (US) | 1994-06-08 | — | — | CN | claimed |
| EP-0582829-A1 | 9-(substituted glycyl) amido - 6-demethyl-6-deoxytetracyclines as antibiotic agents | AMERICAN CYANAMID COMPANY (US) | 1994-02-16 | — | — | EP | claimed |
| US-5173493-A | For treatment or prevention of nausea or vomiting | FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) | 1992-12-22 | — | — | US | claimed |
| US-5141945-A | 5-Hydroxytryptamine antagonists, treatment or prevention of nausea and vomiting | FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) | 1992-08-25 | — | — | US | claimed |
| US-4992447-A | Asthma | PFIZER INC. (US) | 1991-02-12 | — | — | US | claimed |
| EP-0361317-A2 | Pyridoindole derivatives and processes for preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1990-04-04 | — | — | EP | claimed |
| US-4853392-A | Fused 1,4-dihydropyridines as antiallergy and antiinflammatory agents | PFIZER INC. (US) | 1989-08-01 | — | — | US | claimed |
| US-4140858-A | 3-(1H-imidazol-1-ylmethyl)-2-(disubstitutedaminomethyl)indoles and a method for their production | WARNER-LAMBERT COMPANY (US) | 1979-02-20 | — | — | US | claimed |
| JP-63033377-A | — | — | None | — | — | JP | disclosed |
| US-4399137-A | 6-Imidazol-1-yl-3-hydrazino-pyridazines, their preparation and antihypertensive use | BASF AKTIENGESELLSCHAFT (DE) | 1983-08-16 | — | — | US | disclosed |
| US-4140858-A | 3-(1H-imidazol-1-ylmethyl)-2-(disubstitutedaminomethyl)indoles and a method for their production | WARNER-LAMBERT COMPANY (US) | 1979-02-20 | — | — | US | disclosed |