Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6746126 | 1.00 | LMNA (0.52) | LMNASMN1; SMN2MEN1KMT2AL3MBTL1 | |
| SCHEMBL3198050 | 1.00 | LMNA (0.52) | LMNASMN1; SMN2MEN1KMT2AL3MBTL1 | |
| SCHEMBL6746128 | 1.00 | LMNA (0.52) | LMNASMN1; SMN2MEN1KMT2AL3MBTL1 | |
| SCHEMBL3198060 | 1.00 | LMNA (0.52) | LMNASMN1; SMN2MEN1KMT2AL3MBTL1 | |
| SCHEMBL3194443 | 0.82 | SMN1; SMN2 (0.54) | LMNASMN1; SMN2MEN1KMT2AL3MBTL1 | |
| SCHEMBL3194451 | 0.82 | SMN1; SMN2 (0.54) | LMNASMN1; SMN2MEN1KMT2AL3MBTL1 | |
| SCHEMBL26109454 | 0.80 | ALDH1A1 (0.56) | SMN1; SMN2MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL3199533 | 0.77 | SMN1; SMN2 (0.62) | LMNASMN1; SMN2MEN1KMT2AL3MBTL1 | |
| SCHEMBL3199524 | 0.77 | SMN1; SMN2 (0.62) | LMNASMN1; SMN2MEN1KMT2AL3MBTL1 | |
| SCHEMBL3187800 | 0.76 | SMN1; SMN2 (0.50) | LMNASMN1; SMN2MEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379249-A4 | FUSED CYCLIC SUCCINIMIDE COMPOUNDS AND ANALOGS THEREOF, MODULATORS OF NUCLEAR HORMONE RECEPTOR FUNCTION | BRISTOL MYERS SQUIBB CO (US) | 2008-01-09 | — | — | EP | claimed |
| EP-1379249-A1 | FUSED CYCLIC SUCCINIMIDE COMPOUNDS AND ANALOGS THEREOF, MODULATORS OF NUCLEAR HORMONE RECEPTOR FUNCTION | Bristol-Myers Squibb Company (US) | 2004-01-14 | — | — | EP | claimed |
| WO-2002067939-A1 | FUSED CYCLIC SUCCINIMIDE COMPOUNDS AND ANALOGS THEREOF, MODULATORS OF NUCLEAR HORMONE RECEPTOR FUNCTION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-09-06 | — | — | WO | claimed |