Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 4/20 | 0.36 |
| ▸ | CA2 | P00918 | 4/20 | 0.36 |
| ▸ | CA4 | P22748 | 4/20 | 0.36 |
| ▸ | CA6 | P23280 | 4/20 | 0.36 |
| ▸ | CA7 | P43166 | 4/20 | 0.36 |
| ▸ | CA9 | Q16790 | 4/20 | 0.36 |
| ▸ | CA13 | Q8N1Q1 | 4/20 | 0.36 |
| ▸ | CA5B | Q9Y2D0 | 3/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | BUB1 | O43683 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4591532 | 0.72 | BRD4 (0.36) | BRD4 | |
| SCHEMBL5216737 | 0.72 | LMNA (0.30) | — | |
| SCHEMBL5217701 | 0.71 | BRD4 (0.42) | BRD4 | |
| SCHEMBL121399 | 0.64 | BRD4 (1.00) | BRD4CA1CA2CA4CA6 | |
| SCHEMBL30193882 | 0.64 | BRD4 (1.00) | BRD4CA1CA2CA4CA6 | |
| SCHEMBL28154981 | 0.64 | BRD4 (0.68) | BRD4KMT2ACA1CA2CA4 | |
| SCHEMBL16865999 | 0.63 | BRD4 (0.67) | BRD4CA1CA2CA4CA6 | |
| SCHEMBL18566779 | 0.62 | BRD4 (0.59) | BRD4KMT2ACA1CA2CA4 | |
| SCHEMBL20875983 | 0.62 | BRD4 (0.64) | BRD4KMT2ACA1CA2CA4 | |
| SCHEMBL11622652 | 0.62 | MAPT (0.66) | BRD4KMT2ACA1CA2CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899341-A1 | SPIRO-IMIDAZNAPHTHYRIDINE DERIVATIVES AS GASTRIC ACID SECRETION INHIBITORS | Nycomed GmbH (DE) | 2008-03-19 | — | — | EP | disclosed |
| WO-2006134112-A1 | SPIRO-IMIDAZNAPHTHYRIDINE DERIVATIVES AS GASTRIC ACID SECRETION INHIBITORS | NYCOMED GMBH (DE) | 2006-12-21 | — | — | WO | disclosed |