Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of 1-Naphthol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.65 |
| ▸ | CA2 | P00918 | 3/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA9 | Q16790 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | ERN1 | O75460 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 1-Naphthol SCHEMBL30669386 | 0.92 | CYP1A2 (0.77) | CYP1A2CA2CA1CA9KDM4E | |
| 1-Naphthol SCHEMBL7714764 | 0.92 | CYP1A2 (0.77) | CYP1A2CA2CA1CA9KDM4E | |
| 1-Naphthol SCHEMBL10605020 | 0.90 | CYP1A2 (0.74) | CYP1A2CA2CA1CA9KDM4E | |
| 1-Naphthol SCHEMBL10605017 | 0.90 | CYP1A2 (0.74) | CYP1A2CA2CA1CA9KDM4E | |
| 1-Naphthol SCHEMBL28395998 | 0.90 | CYP1A2 (0.74) | CYP1A2CA2CA1CA9KDM4E | |
| 1-Naphthol SCHEMBL27594854 | 0.86 | CYP1A2 (0.74) | CYP1A2CA2CA1CA9KDM4E | |
| 1-Naphthol SCHEMBL29216682 | 0.84 | CYP1A2 (0.71) | CYP1A2CA2CA1CA9KDM4E | |
| 1-Naphthol SCHEMBL28825167 | 0.84 | CYP1A2 (0.71) | CYP1A2CA2CA1CA9KDM4E | |
| 1-Naphthol SCHEMBL28748211 | 0.82 | CYP1A2 (0.74) | CYP1A2CA2CA1CA9KDM4E | |
| 1-Naphthol SCHEMBL10486461 | 0.81 | CYP1A2 (1.00) | CYP1A2CA2KDM4EHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1564591-B1 | Polymerizable composition | FUJIFILM CORP (JP) | 2016-08-03 | — | — | EP | disclosed |
| EP-1927889-B1 | Lithographic printing plate precursor | FUJIFILM CORP (JP) | 2014-06-25 | — | — | EP | disclosed |
| EP-1927889-A1 | Lithographic printing plate precursor | FUJIFILM Corporation (JP) | 2008-06-04 | — | — | EP | disclosed |
| US-7374863-B2 | Polyurethane binder, photoinitiator, and acrylic acid; for use as image recording layer of negative lithographic printing plate precursor; drawing with laser light | FUJIFILM CORPORATION (JP) | 2008-05-20 | — | — | US | disclosed |
| EP-1403042-B1 | Planographic printing plate precursor | FUJIFILM CORP (JP) | 2007-03-14 | — | — | EP | disclosed |
| US-7081329-B2 | Planographic printing plate precursor | FUJI PHOTO FILM CO., LTD. (JP) | 2006-07-25 | — | — | US | disclosed |
| EP-1564591-A2 | Polymerizable composition | FUJI PHOTO FILM CO., LTD. (JP) | 2005-08-17 | — | — | EP | disclosed |
| US-20050170285-A1 | Polyurethane binder, photoinitiator, and acrylic acid; for use as image recording layer of negative lithographic printing plate precursor; drawing with laser light | FUJI PHOTO FILM CO., LTD. | 2005-08-04 | — | — | US | disclosed |
| US-20040131971-A1 | Planographic printing plate precursor | FUJI PHOTO FILM CO., LTD. | 2004-07-08 | — | — | US | disclosed |
| EP-1403042-A2 | Planographic printing plate precursor | FUJI PHOTO FILM CO., LTD. (JP) | 2004-03-31 | — | — | EP | disclosed |
| US-6558873-B1 | Interlayer containing a compound capable of forming a complex with aluminum and a photopolymerizable photosensitive layer containing a photopolymerization initiator, an addition polymerizable compound capable of complexing with aluminum | FUJI PHOTO FILM CO., LTD. (JP) | 2003-05-06 | — | — | US | disclosed |
| EP-1091251-A2 | Lithographic printing plate precursor | FUJI PHOTO FILM CO., LTD. (JP) | 2001-04-11 | — | — | EP | disclosed |