Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of 1-Naphthol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.77 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | CDK2 | P24941 | 1/20 | 0.50 |
| ▸ | ERN1 | O75460 | 1/20 | 0.48 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.46 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | PLAU | P00749 | 1/20 | 0.45 |
| ▸ | LDHA | P00338 | 1/20 | 0.45 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.45 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.45 |
| ▸ | NQO2 | P16083 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 1-Naphthol SCHEMBL30669386 | 1.00 | CYP1A2 (0.77) | CYP1A2CA1CA2CA9KDM4E | |
| 1-Naphthol SCHEMBL28395998 | 0.98 | CYP1A2 (0.74) | CYP1A2CA1CA2CA9KDM4E | |
| 1-Naphthol SCHEMBL10605017 | 0.98 | CYP1A2 (0.74) | CYP1A2CA1CA2CA9KDM4E | |
| 1-Naphthol SCHEMBL10605020 | 0.98 | CYP1A2 (0.74) | CYP1A2CA1CA2CA9KDM4E | |
| 1-Naphthol SCHEMBL27594854 | 0.93 | CYP1A2 (0.74) | CYP1A2CA1CA2CA9KDM4E | |
| 1-Naphthol SCHEMBL4591799 | 0.92 | CYP1A2 (0.65) | CYP1A2CA1CA2CA9KDM4E | |
| 1-Naphthol SCHEMBL29216682 | 0.91 | CYP1A2 (0.71) | CYP1A2CA1CA2CA9KDM4E | |
| 1-Naphthol SCHEMBL28825167 | 0.91 | CYP1A2 (0.71) | CYP1A2CA1CA2CA9KDM4E | |
| 1-Naphthol SCHEMBL28748211 | 0.89 | CYP1A2 (0.74) | CYP1A2CA1CA2CA9KDM4E | |
| 1-Naphthol SCHEMBL10486461 | 0.88 | CYP1A2 (1.00) | CYP1A2CA2KDM4EPTPN22IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107245113-B | Stigma Maydis polysaccharide extract with anticancer effect and its preparation method | 吉林化工学院 | 2020-12-11 | — | — | CN | claimed |
| CN-107245113-A | Corn silk polysaccharide extract with antitumaous effect and preparation method thereof | 吉林化工学院 | 2017-10-13 | — | — | CN | claimed |
| US-6475531-B1 | Safe botanical drug for treatment and prevention of influenza and increasing immune function | L.Y. (HK) BIOTECH LIMITED (HK) | 2002-11-05 | — | — | US | claimed |
| EP-0331821-A1 | Antiviral agent | KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1989-09-13 | — | — | EP | claimed |
| EP-0212501-A2 | Therapeutic agent for treating hematopoietic diseases | GREEN CROSS CORPORATION (JP) | 1987-03-04 | — | — | EP | claimed |
| JP-60034186-A | — | — | None | — | — | JP | disclosed |
| JP-63316730-A | — | — | None | — | — | JP | disclosed |
| CN-113249419-B | Method for synthesizing rhamnolipid by extracellular enzyme catalysis | 南京工业大学 | 2023-10-27 | — | — | CN | disclosed |
| CN-115992064-A | Sea monad and its application | 山东大学威海工业技术研究院 | 2023-04-21 | — | — | CN | disclosed |
| CN-113481140-A | Method for improving rhamnolipid yield and genetic engineering bacteria | 南京工业大学 | 2021-10-08 | — | — | CN | disclosed |
| CN-109266640-B | Method for preparing composite carrier by using modified carbon fiber and polyurethane as raw materials | 河南工业大学 | 2021-09-24 | — | — | CN | disclosed |
| CN-113249419-A | Method for synthesizing rhamnolipid by extracellular enzyme catalysis | 南京工业大学 | 2021-08-13 | — | — | CN | disclosed |
| EP-0331821-A1 | Antiviral agent | KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1989-09-13 | — | — | EP | disclosed |
| JP-S63316730-A | ANTIVIRAL AGENT | KUREHA CHEM IND CO LTD | 1988-12-26 | — | — | JP | disclosed |
| EP-0295956-A2 | Use of a protein-bound polysaccharide for making a drug for treating AIDS. | KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1988-12-21 | — | — | EP | disclosed |
| EP-0212501-A2 | Therapeutic agent for treating hematopoietic diseases | GREEN CROSS CORPORATION (JP) | 1987-03-04 | — | — | EP | disclosed |
| JP-S6034186-A | INHIBITORY SUBSTANCE AGAINST ENZYME CAPABLE OF CONVERTING ANGIOTENSIN I | FUJIREBIO INC | 1985-02-21 | — | — | JP | disclosed |
| US-4481137-A | ANTITUMOR AGENTS FROM CELL CULTURES | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1984-11-06 | — | — | US | disclosed |
| US-4442181-A | NICKEL, TIN, CHROMIUM, CORROSION RESISTANCE | NIPPON STEEL CORPORATION (JP) | 1984-04-10 | — | — | US | disclosed |
| JP-S0634186-A | — | — | 0001-01-01 | — | — | JP | disclosed |