Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.50 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | ESR1 | P03372 | 2/20 | 0.47 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | EBP | Q15125 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4592183 | 0.85 | KDM4E (0.58) | KDM4EBIRC5SMN1; SMN2MAPTCHRNA7 | |
| SCHEMBL7940396 | 0.83 | HPGD (0.57) | KDM4EBIRC5S1PR4SMN1; SMN2MAPT | |
| SCHEMBL5433176 | 0.82 | KDM4E (0.55) | KDM4EBIRC5SMN1; SMN2MAPTCHRNA7 | |
| SCHEMBL2004375 | 0.81 | S1PR4 (0.51) | S1PR4SMN1; SMN2MAPTKMT2ATDP1 | |
| SCHEMBL8903264 | 0.80 | MAPT (0.60) | S1PR4SMN1; SMN2MAPTKMT2ATDP1 | |
| SCHEMBL6142499 | 0.80 | BIRC5 (0.50) | KDM4EBIRC5S1PR4SMN1; SMN2MAPT | |
| SCHEMBL4591966 | 0.80 | KDR (0.56) | KDM4EBIRC5ESR1SMN1; SMN2KDR | |
| SCHEMBL3857536 | 0.80 | MAOA (0.57) | KDM4EBIRC5SMN1; SMN2MAPTKMT2A | |
| SCHEMBL8536866 | 0.80 | MAPT (0.51) | S1PR4SMN1; SMN2MAPTKMT2ATDP1 | |
| SCHEMBL2427826 | 0.79 | KDM4E (0.52) | KDM4EMCHR1BIRC5PTPN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943231-A1 | (HETERO)ARYL COMPOUNDS WITH MCH ANTAGONISTIC ACTIVITY AND MEDICAMENTS COMPRISING THESE COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-07-16 | — | — | EP | disclosed |
| US-20070111981-A1 | New (hetero)aryl compounds with MCH antagonistic activity and medicaments comprising these compounds | ROTH GERALD J | 2007-05-17 | — | — | US | disclosed |
| WO-2007048802-A1 | (HETERO)ARYL COMPOUNDS WITH MCH ANTAGONISTIC ACTIVITY AND MEDICAMENTS COMPRISING THESE COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-05-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070111981-A1 | New (hetero)aryl compounds with MCH antagonistic activity and medicaments comprising these compounds | MCHR1, GPR119, MCHR2 | KDM4E 1313/4885MCHR1 1/4885BIRC5 2273/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.