Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | APEX1 | P27695 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7394370 | 0.83 | KDM4E (0.54) | KDM4EAPEX1ALDH1A1POLBMAPT | |
| SCHEMBL9207480 | 0.80 | KDM4E (0.56) | KDM4EALDH1A1POLBGLAMEN1 | |
| SCHEMBL28253810 | 0.79 | AVPR2 (0.37) | KDM4EALDH1A1POLBHPGD | |
| SCHEMBL2827984 | 0.79 | ALDH1A1 (0.59) | KDM4EALDH1A1MAPTHTTMEN1 | |
| SCHEMBL2825664 | 0.79 | MMP2 (0.49) | KDM4EALDH1A1POLBMEN1KMT2A | |
| SCHEMBL11842214 | 0.78 | APEX1 (0.50) | KDM4EAPEX1ALDH1A1POLBMAPT | |
| SCHEMBL22092291 | 0.77 | APEX1 (0.48) | KDM4EAPEX1ALDH1A1MAPTGLA | |
| Toluene SCHEMBL9554519 | 0.76 | KDM4E (0.52) | KDM4EAPEX1ALDH1A1POLBMAPT | |
| SCHEMBL9545148 | 0.75 | POLB (0.48) | KDM4EALDH1A1POLBMAPTHPGD | |
| SCHEMBL21384059 | 0.75 | TP53 (0.43) | KDM4EALDH1A1POLBMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2880033-B1 | CYCLIC UREA- OR LACTAM-SUBSTITUTED QUINOXALINE-TYPE PIPERIDINE COMPOUNDS AND THE USES THEREOF | PURDUE PHARMA LP (US) | 2020-06-17 | — | — | EP | disclosed |
| WO-2018193387-A1 | HETEROCYCLIC COMPOUNDS WITH MICROBIOCIDAL PROPERTIES | PI INDUSTRIES LTD. (IN) | 2018-10-25 | — | — | WO | disclosed |
| US-9085561-B2 | Cyclic urea- or lactam-substituted quinoxaline-type piperidines as ORL-1 modulators | PURDUE PHARMA L.P. (US) | 2015-07-21 | — | — | US | disclosed |
| CN-101287738-B | Imidazo benzodiazepine derivatives | HOFFMANN LA ROCHE | 2011-08-10 | — | — | CN | disclosed |
| CN-101287738-A | Imidazo benzodiazepine derivatives | HOFFMANN LA ROCHE (CH) | 2008-10-15 | — | — | CN | disclosed |
| EP-1937688-A1 | IMIDAZO BENZODIAZEPINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007042421-A1 | IMIDAZO BENZODIAZEPINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-04-19 | — | — | WO | disclosed |
| US-3994874-A | ANTIBACTERIAL | RICHARDSON-MERRELL INC. (US) | 1976-11-30 | — | — | US | disclosed |
| US-3956287-A | BACTERICIDES | RICHARDSON-MERRELL INC. (US) | 1976-05-11 | — | — | US | disclosed |