Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CXCR5 | P32302 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29192390 | 0.80 | BRD4 (0.38) | BRD4GAAKMT2AMEN1NPC1 | |
| SCHEMBL16669626 | 0.74 | BRD4 (0.48) | BRD4GAAKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL13886265 | 0.69 | BRD4 (0.39) | BRD4GAASMN1; SMN2NPC1MAPT | |
| SCHEMBL5837737 | 0.67 | BRD4 (0.42) | BRD4GAAKMT2AMEN1NPC1 | |
| SCHEMBL9752039 | 0.67 | MAPT (0.39) | BRD4GAAKMT2AMEN1NPC1 | |
| SCHEMBL38660901 | 0.67 | MAPT (0.39) | BRD4GAAKMT2AMEN1NPC1 | |
| SCHEMBL6773172 | 0.67 | BRD4 (0.42) | BRD4GAAKMT2AMEN1NPC1 | |
| SCHEMBL13869013 | 0.67 | BRD4 (0.38) | BRD4GAASMN1; SMN2NPC1MAPT | |
| SCHEMBL29192329 | 0.67 | BRD4 (0.40) | BRD4GAAKMT2AMEN1MAPT | |
| SCHEMBL10907418 | 0.67 | BRD4 (0.55) | BRD4GAASMN1; SMN2MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807398-B1 | NEW INDOLE OR BENZIMIDAZOLE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2008-06-25 | — | — | EP | disclosed |