SCHEMBL4592476

SCHEMBL4592476

NC(=O)C1CC(=O)c2ccc[c]c2O1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.36
PARP1 P09874 1/20 0.35
ADORA3 P0DMS8 3/20 0.33
MAOB P27338 3/20 0.33
AR P10275 2/20 0.33
KDM4E B2RXH2 1/20 0.33
CYP19A1 P11511 1/20 0.33
HSD17B10 Q99714 1/20 0.33
RAB9A P51151 3/20 0.33
NPC1 O15118 2/20 0.33
HSD11B1 P28845 1/20 0.33
AKR1C3 P42330 1/20 0.33
CYP3A4 P08684 1/20 0.33
MAPT P10636 1/20 0.33
MAPK1 P28482 1/20 0.33
LMNA P02545 1/20 0.31
AXL P30530 1/20 0.31
KMT2A Q03164 2/20 0.30
S100A4 P26447 1/20 0.30
MEN1 O00255 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29499451 0.74 MAOB (0.56) SMN1; SMN2ADORA3MAOBARKDM4E
SCHEMBL12561159 0.74 MAOB (0.56) SMN1; SMN2ADORA3MAOBARKDM4E
SCHEMBL6937054 0.71 CYP19A1 (0.33) MAOBCYP19A1CYP3A4MAPTALDH1A1
SCHEMBL3342928 0.70 SIRT1 (0.38) HPGDATM
SCHEMBL1294648 0.66 SMN1; SMN2 (0.75) SMN1; SMN2KDM4ERAB9ANPC1MAPT
SCHEMBL10885954 0.64 MAOB (0.39) SMN1; SMN2MAOBRAB9ANPC1ALDH1A1
SCHEMBL5801310 0.64 PARP1 (0.34) SMN1; SMN2PARP1KDM4EHSD17B10RAB9A
SCHEMBL22624375 0.64 AR (0.54) SMN1; SMN2MAOBARKDM4ECYP19A1
SCHEMBL22624453 0.64 AR (0.54) SMN1; SMN2MAOBARKDM4ECYP19A1
SCHEMBL22617253 0.61 MAOB (0.60) SMN1; SMN2ADORA3MAOBARKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1981493-A1 ACAT INHIBITORS AND THEIR USE IN THE PREVENTION OR TREATMENT OF FIBROSIS Chronogen Inc. (CA) 2008-10-22 EP disclosed
WO-2008058383-A1 ACAT INHIBITORS AND THEIR USE IN THE PREVENTION OR TREATMENT OF FIBROSIS CHRONOGEN INC. (CA) 2008-05-22 WO disclosed