Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.32 |
| ▸ | LDHA | P00338 | 2/20 | 0.32 |
| ▸ | LDHB | P07195 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 3/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.30 |
| ▸ | PGK1 | P00558 | 1/20 | 0.30 |
| ▸ | IKBKB | O14920 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9017615 | 0.87 | SIRT1 (0.35) | LMNAHTTSIRT1POLBRIPK2 | |
| SCHEMBL9017622 | 0.77 | POLB (0.35) | LMNAHTTSIRT1POLBRIPK2 | |
| SCHEMBL8732692 | 0.75 | SIRT1 (0.36) | LMNASIRT1TSHRRIPK2ALDH1A1 | |
| SCHEMBL9017621 | 0.72 | IKBKB (0.39) | LMNAHTTPOLBRIPK2IKBKB | |
| SCHEMBL28068800 | 0.70 | POLB (0.39) | HTTSIRT1POLBLDHALDHB | |
| SCHEMBL8083612 | 0.69 | GAA (0.34) | LMNAHTTSIRT1POLBTSHR | |
| SCHEMBL10495743 | 0.69 | GPR17 (0.39) | — | |
| SCHEMBL21236340 | 0.69 | POLB (0.38) | LMNASIRT1POLBTSHRRIPK2 | |
| SCHEMBL3352707 | 0.68 | ALDH1A1 (0.41) | LMNAHTTSIRT1POLBTSHR | |
| Hydrochloric Acid SCHEMBL8075471 | 0.68 | GAA (0.33) | LMNAHTTSIRT1POLBTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008124085-A2 | METHODS OF USING COMBINATIONS OF MEK AND JAK-2 INHIBITORS | EXELIXIS, INC. (US) | 2008-10-16 | — | — | WO | disclosed |