Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL461375 | 0.64 | ATM (0.36) | ALDH1A1POLB | |
| SCHEMBL27647151 | 0.60 | NOS1 (0.37) | MAPT | |
| SCHEMBL21093634 | 0.57 | GRIN2B (0.44) | ALDH1A1 | |
| SCHEMBL7033011 | 0.57 | ALDH1A1 (0.46) | ABCB1ALDH1A1 | |
| SCHEMBL13971270 | 0.57 | ALDH1A1 (0.46) | ABCB1ALDH1A1 | |
| SCHEMBL7565494 | 0.57 | GBA1 (0.45) | POLB | |
| SCHEMBL23467257 | 0.56 | ALDH1A1 (0.44) | ALDH1A1 | |
| SCHEMBL4609517 | 0.56 | GBA1 (0.50) | — | |
| SCHEMBL7810455 | 0.56 | GRIN2B (0.46) | — | |
| SCHEMBL8979913 | 0.56 | CA1 (0.55) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2595972-A1 | TRICYCLIC LACTONES FOR TREATMENT OF CANCER | Glactone Pharma Development AB (SE) | 2013-05-29 | — | — | EP | disclosed |
| WO-2012010555-A1 | TRICYCLIC LACTONES FOR TREATMENT OF CANCER | PARTNERS FÖR UTVECKLINGSINVESTERINGAR INOM LIFE SCIENCES, P.U.L.S. AB (SE) | 2012-01-26 | — | — | WO | disclosed |