Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 5/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | TGM2 | P21980 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| P-Xylene SCHEMBL22832066 | 0.92 | ACHE (0.42) | ACHETDP1CYP2A6IDO1ALDH1A1 | |
| P-Xylene SCHEMBL6136954 | 0.85 | ACHE (0.55) | ACHETDP1IDO1ALDH1A1NPC1 | |
| P-Xylene SCHEMBL27502894 | 0.79 | TSHR (0.53) | ACHETDP1CYP2A6IDO1ALDH1A1 | |
| SCHEMBL8897251 | 0.78 | HRH3 (0.36) | TDP1ALDH1A1SMN1; SMN2MAPTTSHR | |
| O-Xylene SCHEMBL11054463 | 0.77 | TSHR (0.56) | ACHETDP1CYP2A6ALDH1A1CA1 | |
| P-Xylene SCHEMBL28049921 | 0.76 | ACHE (0.61) | ACHETDP1CYP2A6IDO1ALDH1A1 | |
| SCHEMBL4950820 | 0.75 | TSHR (0.50) | TDP1ALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL10862 | 0.75 | — | — | |
| SCHEMBL3814841 | 0.75 | — | — | |
| SCHEMBL2430668 | 0.75 | TSHR (0.50) | TDP1ALDH1A1SMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1081140-B1 | Novel Pyrimidine-2,4,6-trione compounds | DSM IP ASSETS BV (NL) | 2005-06-01 | — | — | EP | claimed |
| EP-1000950-B1 | Novel indanylidene compounds | HOFFMANN LA ROCHE (CH) | 2004-02-25 | — | — | EP | claimed |
| US-6416746-B1 | ULTRAVIOLET RAY AND LIGHT SCREENING MATERIAL GRAFTED TO SILANE, OLIGOSILOXANE, OR POLYSILOXANE WITH IMPROVED SOLUBILITY AND LITTLE PENETRATION; FOR USE IN COSMETICS | ROCHE VITAMINS INC. | 2002-07-09 | — | — | US | claimed |
| EP-1081140-A2 | Novel Pyrimidine-2,4,6-trione compounds | F. HOFFMANN-LA ROCHE AG (CH) | 2001-03-07 | — | — | EP | claimed |
| EP-1000950-A2 | Novel indanylidene compounds | F. HOFFMANN-LA ROCHE AG (CH) | 2000-05-17 | — | — | EP | claimed |
| EP-3019142-B1 | UV SCREENING COMPOSITION COMPRISING A UV FILTER, AN ORGANOPOLYSILOXANE FUNCTIONALIZED WITH A UV ABSORBER AND POROUS SILICA AND / OR POLYMETHYLMETHACRYLATE PARTICLES | DSM IP ASSETS BV (NL) | 2017-10-04 | — | — | EP | disclosed |
| US-20160143831-A1 | UV SCREENING COMPOSITION COMPRISING A UV FILTER, AN ORGANOPOLYSILOXANE FUNCTIONALIZED WITH A UV ABSORBER AND POROUS SILICA AND/OR POLYMETHYLMETHACRYLATE PARTICLES | DSM IP ASSETS B.V. (NL) | 2016-05-26 | — | — | US | disclosed |
| EP-3019142-A1 | UV SCREENING COMPOSITION COMPRISING A UV FILTER, AN ORGANOPOLYSILOXANE FUNCTIONALIZED WITH A UV ABSORBER AND POROUS SILICA AND/OR POLYMETHYLMETHACRYLATE PARTICLES | DSM IP Assets B.V. (NL) | 2016-05-18 | — | — | EP | disclosed |
| WO-2015003987-A1 | UV SCREENING COMPOSITION COMPRISING A UV FILTER, AN ORGANOPOLYSILOXANE FUNCTIONALIZED WITH A UV ABSORBER AND POROUS SILICA AND/OR POLYMETHYLMETHACRYLATE PARTICLES | DSM IP ASSETS B.V. (NL) | 2015-01-15 | — | — | WO | disclosed |
| US-8492575-B2 | Method for improving the color index of organopolysiloxanes | DSM IP ASSETS B.V. (NL) | 2013-07-23 | — | — | US | disclosed |
| US-8481775-B2 | Method for improving the color index of organopolysiloxanes | DSM IP ASSETS B.V. (NL) | 2013-07-09 | — | — | US | disclosed |
| EP-2352778-B1 | PROCESS | DSM IP ASSETS BV (NL) | 2013-02-27 | — | — | EP | disclosed |
| EP-1250300-B1 | ALKYLATION PROCESS | OPTATECH CORP (FI) | 2004-12-15 | — | — | EP | disclosed |
| EP-1000950-B1 | Novel indanylidene compounds | HOFFMANN LA ROCHE (CH) | 2004-02-25 | — | — | EP | disclosed |
| WO-2003086340-A1 | ORGANOSILICONE DERIVATIVES OF AMINO HYDROXYBENZOPHENONES AND THEIR USE AS UV-A FILTERS IN COSMETIC PREPARATIONS | DSM IP ASSETS B.V. (NL) | 2003-10-23 | — | — | WO | disclosed |
| US-6573269-B1 | Compounds for protecting surface of substrate from ultraviolet light | ROCHE VITAMINS INC. | 2003-06-03 | — | — | US | disclosed |
| US-6416746-B1 | ULTRAVIOLET RAY AND LIGHT SCREENING MATERIAL GRAFTED TO SILANE, OLIGOSILOXANE, OR POLYSILOXANE WITH IMPROVED SOLUBILITY AND LITTLE PENETRATION; FOR USE IN COSMETICS | ROCHE VITAMINS INC. | 2002-07-09 | — | — | US | disclosed |
| EP-1081140-A2 | Novel Pyrimidine-2,4,6-trione compounds | F. HOFFMANN-LA ROCHE AG (CH) | 2001-03-07 | — | — | EP | disclosed |
| EP-1000950-A2 | Novel indanylidene compounds | F. HOFFMANN-LA ROCHE AG (CH) | 2000-05-17 | — | — | EP | disclosed |
| US-5773676-A | MULTISTAGE PROCESS | PHILLIPS PETROLEUM COMPANY (US) | 1998-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160143831-A1 | UV SCREENING COMPOSITION COMPRISING A UV FILTER, AN ORGANOPOLYSILOXANE FUNCTIONALIZED WITH A UV ABSORBER AND POROUS SILICA AND/OR POLYMETHYLMETHACRYLATE PARTICLES | RAD50, SERPINB10, XRCC5 | ACHE 2987/4885TDP1 3892/4885CYP2A6 1309/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.