P-Xylene

P-Xylene

SCHEMBL6136954

C=CCC.C=CCC.Cc1ccc(C)cc1.Cc1cccc(C)c1

nearest known ligand 0.55

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE P22303 6/20 0.55
TDP1 Q9NUW8 3/20 0.50
TP53 P04637 1/20 0.50
ALDH1A1 P00352 1/20 0.39
MAPK1 P28482 1/20 0.39
CYP1A2 P05177 2/20 0.39
CYP2C19 P33261 2/20 0.39
NPC1 O15118 1/20 0.39
CASP3 P42574 1/20 0.39
SENP8 Q96LD8 1/20 0.39
SENP7 Q9BQF6 1/20 0.39
SENP6 Q9GZR1 1/20 0.39
CYP3A4 P08684 1/20 0.39
CYP2D6 P10635 1/20 0.39
MAPT P10636 1/20 0.39
CYP2C9 P11712 1/20 0.39
HTT P42858 1/20 0.39
LMNA P02545 1/20 0.38
TSHR P16473 1/20 0.38
ALOX12 P18054 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
P-Xylene SCHEMBL459337 0.85 ACHE (0.50) ACHETDP1ALDH1A1CYP1A2NPC1
M-Xylene SCHEMBL4415556 0.83 ACHE (0.63) ACHETDP1TP53ALDH1A1MAPK1
M-Xylene SCHEMBL457254 0.80 ACHE (0.52) ACHETDP1TP53ALDH1A1MAPK1
P-Xylene SCHEMBL1648568 0.80 ACHE (0.86) ACHETDP1TP53ALDH1A1MAPK1
P-Xylene SCHEMBL11760571 0.80 ACHE (0.86) ACHETDP1TP53ALDH1A1MAPK1
P-Xylene SCHEMBL27724437 0.80 ACHE (0.86) ACHETDP1TP53ALDH1A1MAPK1
P-Xylene SCHEMBL22832066 0.78 ACHE (0.42) ACHETDP1ALDH1A1CYP1A2NPC1
M-Xylene SCHEMBL11483190 0.78 ACHE (0.71) ACHETDP1TP53ALDH1A1MAPK1
M-Xylene SCHEMBL458857 0.78 ACHE (0.71) ACHETDP1TP53ALDH1A1MAPK1
M-Xylene SCHEMBL28720164 0.77 ACHE (0.80) ACHETDP1TP53ALDH1A1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1081140-B1 Novel Pyrimidine-2,4,6-trione compounds DSM IP ASSETS BV (NL) 2005-06-01 EP disclosed
EP-1000950-B1 Novel indanylidene compounds HOFFMANN LA ROCHE (CH) 2004-02-25 EP disclosed
US-6573269-B1 Compounds for protecting surface of substrate from ultraviolet light ROCHE VITAMINS INC. 2003-06-03 US disclosed
US-6416746-B1 ULTRAVIOLET RAY AND LIGHT SCREENING MATERIAL GRAFTED TO SILANE, OLIGOSILOXANE, OR POLYSILOXANE WITH IMPROVED SOLUBILITY AND LITTLE PENETRATION; FOR USE IN COSMETICS ROCHE VITAMINS INC. 2002-07-09 US disclosed
EP-1081140-A2 Novel Pyrimidine-2,4,6-trione compounds F. HOFFMANN-LA ROCHE AG (CH) 2001-03-07 EP disclosed
EP-1000950-A2 Novel indanylidene compounds F. HOFFMANN-LA ROCHE AG (CH) 2000-05-17 EP disclosed
US-6018044-A TRIS((ALKYL, SILANE, OLIGOSILOXANE OR POLYSILOXANE)(OXY OR AMINO)CARBONYL-(1,4-PHENYLENE)-AMINO)-S-TRIAZINES HAVING AT LEAST ONE SILICON CONTAINING MOIETY OF GIVEN FORMULA; USE AS UV-B FILTERS IN LIGHT SCREENING COMPOSITIONS ROCHE VITAMINS INC. (US) 2000-01-25 US disclosed
EP-0933376-A2 Silanyl-triazines as light screening compositions F. HOFFMANN-LA ROCHE AG (CH) 1999-08-04 EP disclosed