⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29488781 | 0.97 | — | — | |
| SCHEMBL11837 | 0.97 | — | — | |
| Bromide SCHEMBL27519869 | 0.94 | — | — | |
| Fluoride SCHEMBL21816907 | 0.94 | ACHE (0.94) | — | |
| SCHEMBL28136915 | 0.94 | — | — | |
| Hydrochloric Acid SCHEMBL29088489 | 0.94 | ACHE (0.94) | — | |
| SCHEMBL29176814 | 0.94 | — | — | |
| Hydrochloric Acid SCHEMBL28105763 | 0.94 | ACHE (0.94) | — | |
| Fluoride SCHEMBL28142665 | 0.94 | — | — | |
| Iodide SCHEMBL27592623 | 0.94 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113292510-B | Benzisothiazole compound for inhibiting hypoxia inducible factor 2 activity, preparation method and application thereof | 中国药科大学 | 2022-08-26 | — | — | CN | disclosed |
| CN-113292510-A | Benzisothiazole compound for inhibiting hypoxia inducible factor 2 activity, preparation method and application thereof | 中国药科大学 | 2021-08-24 | — | — | CN | disclosed |
| EP-3356348-B1 | 2-AMINOQUINAZOLINE DERIVATIVES AS P70S6 KINASE INHIBITORS | SENTINEL ONCOLOGY LTD (GB) | 2021-05-05 | — | — | EP | disclosed |
| CN-108473472-B | 2-aminoquinazoline derivatives as P70S6kinase inhibitors | 圣提内尔肿瘤学有限公司 | 2021-02-12 | — | — | CN | disclosed |
| US-10730882-B2 | 2-aminoquinazoline derivatives as P70S6 kinase inhibitors | SENTINEL ONCOLOGY LIMITED (GB) | 2020-08-04 | — | — | US | disclosed |
| US-20190292195-A1 | 2-AMINOQUINAZOLINE DERIVATIVES AS P70S6 KINASE INHIBITORS | SENTINEL ONCOLOGY LIMITED (GB) | 2019-09-26 | — | — | US | disclosed |
| US-10344033-B2 | 2-aminoquinazoline derivatives as P70S6 kinase inhibitors | SENTINEL ONCOLOGY LIMITED (GB) | 2019-07-09 | — | — | US | disclosed |
| US-20180370975-A1 | 2-AMINOQUINAZOLINE DERIVATIVES AS P70S6 KINASE INHIBITORS | SENTINEL ONCOLOGY LIMITED (GB) | 2018-12-27 | — | — | US | disclosed |
| CN-108473433-A | The method for preparing the quinoline of Polyfluoroalkyl | 拜耳作物科学股份公司 | 2018-08-31 | — | — | CN | disclosed |
| CN-108369222-A | Opioid receptor modulators and uses thereof | 明尼苏达大学董事会 | 2018-08-03 | — | — | CN | disclosed |
| CN-107847498-A | tetra-substituted olefin compound and use thereof | 卫材R&D管理有限公司 | 2018-03-27 | — | — | CN | disclosed |
| CN-107635980-A | Glucosylceramide Synthase Inhibitors For The Treatment Of Diseases | 生物马林药物股份有限公司 | 2018-01-26 | — | — | CN | disclosed |
| CN-104744475-B | MTOR kinase inhibitors for the tumour indication and disease related to mTOR/PI3K/AKT/ approach | 西格诺药品有限公司 | 2018-01-12 | — | — | CN | disclosed |
| CN-107108634-A | Imidazopyridazine derivatives as PI3K beta inhibitors | 詹森药业有限公司 | 2017-08-29 | — | — | CN | disclosed |
| CN-107072976-A | Pharmaceutical composition comprising Danirixin for the treatment of infectious diseases | 葛兰素史克知识产权第二有限公司 | 2017-08-18 | — | — | CN | disclosed |
| CN-107001372-A | Substituted aminopurine compounds, compositions thereof, and methods of treatment therewith | 西格诺药品有限公司 | 2017-08-01 | — | — | CN | disclosed |
| CN-103664973-B | Spiro-oxindole compounds and their use as therapeutic agents | 泽农医药公司 | 2017-04-19 | — | — | CN | disclosed |
| CN-102256983-B | Spirooxindole compounds and their use as therapeutic agents | 泽农医药公司 | 2017-04-05 | — | — | CN | disclosed |
| EP-1926719-A2 | 2-ANILINE-4-ARYL SUBSTITUTED THIAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-06-04 | — | — | EP | disclosed |
| WO-2007031440-A2 | 2-ANILINE-4-ARYL SUBSTITUTED THIAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-03-22 | — | — | WO | disclosed |