Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 5/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 5/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 5/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 7/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 7/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
| ▸ | MMP8 | P22894 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7076732 | 0.71 | CYP11B1 (0.43) | MAPK13MAPK12MAPK11MAPK14CYP11B1 | |
| SCHEMBL27550009 | 0.70 | CYP11B1 (0.56) | CYP11B1CYP11B2IDO1 | |
| SCHEMBL7748830 | 0.67 | NFATC1 (0.58) | MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL1948648 | 0.66 | CYP11B1 (0.48) | CYP11B1CYP11B2LMNAHPGDIDO1 | |
| SCHEMBL593796 | 0.65 | CYP11B1 (0.58) | CYP11B1CYP11B2HPGDIDO1 | |
| SCHEMBL27984310 | 0.64 | CYP11B1 (0.51) | CYP11B1CYP11B2LMNAIDO1 | |
| SCHEMBL6751976 | 0.64 | KMT2A (0.53) | LMNAHPGD | |
| SCHEMBL1950305 | 0.63 | CYP11B1 (0.48) | CYP11B1CYP11B2IDO1 | |
| SCHEMBL10983627 | 0.63 | IDO1 (0.44) | MAPK14CYP11B1CYP11B2LMNAIDO1 | |
| SCHEMBL15653534 | 0.63 | CYP11B1 (0.54) | CYP11B1CYP11B2IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1583535-A4 | METHODS FOR TREATING DIABETES | SCIOS INC (US) | 2008-03-19 | — | — | EP | disclosed |
| EP-1583535-A2 | METHODS FOR TREATING DIABETES | SCIOS INC. (US) | 2005-10-12 | — | — | EP | disclosed |
| WO-2004053107-A2 | METHODS FOR TREATING DIABETES | SCIOS INC. (US) | 2004-06-24 | — | — | WO | disclosed |