Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 8/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 8/20 | 0.43 |
| ▸ | IDO1 | P14902 | 2/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 7/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 7/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 7/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.33 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.33 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.33 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.33 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.32 |
| ▸ | FRK | P42685 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27550009 | 0.73 | CYP11B1 (0.56) | CYP11B1CYP11B2IDO1 | |
| SCHEMBL8156007 | 0.72 | MAPK13 (0.69) | MAPK13MAPK12MAPK11MAPK14MAP4K4 | |
| SCHEMBL4593524 | 0.71 | MAPK13 (0.42) | CYP11B1CYP11B2IDO1MAPK13MAPK12 | |
| SCHEMBL7748830 | 0.69 | NFATC1 (0.58) | MAPK13MAPK12MAPK11MAPK14GSK3B | |
| SCHEMBL593796 | 0.68 | CYP11B1 (0.58) | CYP11B1CYP11B2IDO1ALDH1A1RAB9A | |
| SCHEMBL27984310 | 0.67 | CYP11B1 (0.51) | CYP11B1CYP11B2IDO1ALDH1A1RAB9A | |
| SCHEMBL10983627 | 0.66 | IDO1 (0.44) | CYP11B1CYP11B2IDO1MAPK14ALDH1A1 | |
| SCHEMBL15653534 | 0.66 | CYP11B1 (0.54) | CYP11B1CYP11B2IDO1ALDH1A1 | |
| Morpholine SCHEMBL7748831 | 0.65 | CYP11B1 (0.42) | CYP11B1CYP11B2IDO1MAPK13MAPK12 | |
| SCHEMBL1947042 | 0.65 | CYP11B1 (0.58) | CYP11B1CYP11B2IDO1MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0889888-A4 | NOVEL TREATMENT FOR CNS INJURIES | SMITHKLINE BEECHAM CORP (US) | 2003-01-08 | — | — | EP | disclosed |
| US-6150557-A | REACTING COMPOUND CONTAINING SECONDARY AMIDE GROUPS WITH BENZENESULFINIC ACID OR ITS DERIVATIVE IN PRESENCE OF ACID CATALYST | SMITHKLINE BEECHAM CORPORATION (US) | 2000-11-21 | — | — | US | disclosed |
| EP-0889888-A1 | NOVEL TREATMENT FOR CNS INJURIES | SMITHKLINE BEECHAM CORPORATION (US) | 1999-01-13 | — | — | EP | disclosed |
| WO-1997035856-A1 | NOVEL TREATMENT FOR CNS INJURIES | SMITHKLINE BEECHAM CORPORATION (US) | 1997-10-02 | — | — | WO | disclosed |