Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.49 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.48 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.48 |
| ▸ | THRA | P10827 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | EGFR | P00533 | 2/20 | 0.45 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3633941 | 0.84 | GRM2 (0.53) | L3MBTL1HPGDSMN1; SMN2 | |
| SCHEMBL5321630 | 0.84 | TSHR (0.60) | L3MBTL1HPGDSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL10506729 | 0.83 | GSK3B (0.55) | HPGDKMT2AMEN1NR1H2NR1H3 | |
| SCHEMBL26023444 | 0.82 | RXRA (0.58) | HPGDKMT2AMEN1NR1H2NR1H3 | |
| SCHEMBL8002100 | 0.81 | HPGD (0.62) | L3MBTL1HPGDKMT2AMEN1NR1H2 | |
| Butyrophenone SCHEMBL27652073 | 0.78 | L3MBTL1 (0.69) | L3MBTL1HPGDSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL11881187 | 0.78 | NR1H2 (0.62) | KMT2AMEN1NR1H2NR1H3NPC1 | |
| SCHEMBL26023443 | 0.77 | CA1 (0.55) | HPGDSMN1; SMN2KMT2AMEN1NR1H2 | |
| SCHEMBL10345229 | 0.77 | HSD17B3 (0.62) | L3MBTL1HPGDSMN1; SMN2KMT2AMEN1 | |
| Butyrophenone SCHEMBL25423577 | 0.76 | L3MBTL1 (0.77) | L3MBTL1HPGDSMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912649-A2 | QUINOLINE DERIVATIVES AS ANTIBACTERIAL AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007014934-A2 | QUINOLINE DERIVATIVES AS ANTIBACTERIAL AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-02-08 | — | — | WO | disclosed |