Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 4/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 4/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.33 |
| ▸ | ACSL1 | P33121 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | GCG | P01275 | 1/20 | 0.32 |
| ▸ | GCGR | P47871 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4594029 | 0.93 | SSTR5 (0.41) | SSTR5HRH1TACR1TDP1SSTR1 | |
| SCHEMBL4594363 | 0.90 | SSTR5 (0.41) | SSTR5HRH1L3MBTL1SSTR1SLC6A2 | |
| SCHEMBL4594138 | 0.89 | SSTR5 (0.44) | SSTR5HRH1POLBTDP1L3MBTL1 | |
| SCHEMBL4594820 | 0.89 | SSTR5 (0.39) | SSTR5PPARATACR1POLBTDP1 | |
| SCHEMBL4638433 | 0.87 | SSTR5 (0.38) | SSTR5HRH1SSTR1ACSL1SLC6A2 | |
| SCHEMBL4594763 | 0.87 | SSTR5 (0.41) | SSTR5HRH1PPARASSTR1SLC6A2 | |
| SCHEMBL4593365 | 0.87 | SSTR5 (0.36) | SSTR5HRH1TACR1L3MBTL1SLC6A2 | |
| SCHEMBL5484220 | 0.87 | SSTR5 (0.44) | SSTR5HRH1SSTR1SLC6A2SLC6A4 | |
| SCHEMBL4594466 | 0.86 | SSTR5 (0.38) | SSTR5HRH1TACR1SSTR1ACSL1 | |
| SCHEMBL4593843 | 0.86 | SSTR5 (0.43) | SSTR5HRH1SSTR1KCNH2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924579-A2 | BENZOOXAZOLE, OXAZOLOPYRIDINE, BENZOTHIAZOLE AND THIAZOLOPYRIDINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-05-28 | — | — | EP | claimed |
| WO-2007025897-A2 | BENZOOXAZOLE, OXAZOLOPYRIDINE, BENZOTHIAZOLE AND THIAZOLOPYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-03-08 | — | — | WO | claimed |
| EP-1924579-A2 | BENZOOXAZOLE, OXAZOLOPYRIDINE, BENZOTHIAZOLE AND THIAZOLOPYRIDINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007025897-A2 | BENZOOXAZOLE, OXAZOLOPYRIDINE, BENZOTHIAZOLE AND THIAZOLOPYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-03-08 | — | — | WO | disclosed |