Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 7/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.44 |
| ▸ | HRH1 | P35367 | 3/20 | 0.41 |
| ▸ | SSTR1 | P30872 | 2/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 3/20 | 0.34 |
| ▸ | JAK1 | P23458 | 3/20 | 0.34 |
| ▸ | TYK2 | P29597 | 3/20 | 0.34 |
| ▸ | JAK3 | P52333 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4594138 | 0.93 | SSTR5 (0.44) | SSTR5KCNH2HRH1SSTR1HDAC6 | |
| SCHEMBL4593843 | 0.92 | SSTR5 (0.43) | SSTR5KCNH2HRH1SSTR1HDAC6 | |
| SCHEMBL1380236 | 0.88 | SSTR5 (0.54) | SSTR5KCNH2SSTR1HDAC6JAK2 | |
| SCHEMBL4594363 | 0.88 | SSTR5 (0.41) | SSTR5KCNH2HRH1SSTR1HDAC6 | |
| SCHEMBL5485903 | 0.88 | HDAC6 (0.46) | SSTR5KCNH2HRH1SSTR1HDAC6 | |
| SCHEMBL4593393 | 0.87 | SSTR5 (0.42) | SSTR5KCNH2HRH1SSTR1NPC1 | |
| SCHEMBL4593945 | 0.87 | SSTR5 (0.41) | SSTR5KCNH2HRH1SSTR1HDAC6 | |
| SCHEMBL1378217 | 0.86 | SSTR5 (0.49) | SSTR5KCNH2HRH1SSTR1DHFR | |
| SCHEMBL4594029 | 0.85 | SSTR5 (0.41) | SSTR5KCNH2HRH1SSTR1SLC6A2 | |
| SCHEMBL5488609 | 0.85 | SSTR5 (0.41) | SSTR5HRH1DHFRSLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1858901-A1 | BENZOTHIAZOLE, THIAZOLOPYRIDINE, BENZOOXAZOLE AND OXAZOLOPYRIDINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2007-11-28 | — | — | EP | disclosed |
| WO-2006094682-A1 | BENZOTHIAZOLE, THIAZOLOPYRIDINE, BENZOOXAZOLE AND OXAZOLOPYRIDINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-09-14 | — | — | WO | disclosed |