Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 9/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.45 |
| ▸ | PDE4A | P27815 | 6/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.45 |
| ▸ | PARP10 | Q53GL7 | 4/20 | 0.43 |
| ▸ | PARP15 | Q460N3 | 3/20 | 0.43 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.40 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23835159 | 0.80 | PARP10 (0.52) | PARP10PARP15PARP2SIRT2IRAK4 | |
| SCHEMBL28164154 | 0.80 | PDE4B (0.43) | PDE4BPDE4DPDE4APDE4CABCB11 | |
| SCHEMBL14147396 | 0.79 | PARP1 (0.51) | SIRT2 | |
| SCHEMBL6456302 | 0.78 | PDE4B (0.47) | PDE4BPDE4DPDE4APDE4CABCB11 | |
| SCHEMBL28324547 | 0.77 | PARP15 (0.50) | PDE4BPDE4DPDE4APDE4CPARP10 | |
| SCHEMBL4429839 | 0.77 | PDE4B (0.45) | PDE4BPDE4DPDE4APDE4CABCB11 | |
| SCHEMBL5033170 | 0.77 | PDE4D (0.47) | PDE4BPDE4DPDE4APDE4CABCB11 | |
| SCHEMBL874503 | 0.77 | PDE4D (0.41) | PDE4BPDE4DPDE4APDE4CABCB11 | |
| SCHEMBL6877898 | 0.77 | PDE4B (0.43) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL16447382 | 0.76 | PARP10 (0.58) | PDE4BPDE4DPDE4APDE4CPARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1898894-A1 | MRP IV INHIBITORS FOR THE TREATMENT OF RESPIRATORY DISEASES | Boehringer Ingelheim International GmbH (DE) | 2008-03-19 | — | — | EP | claimed |
| WO-2006134022-A1 | MRP IV INHIBITORS FOR THE TREATMENT OF RESPIRATORY DISEASES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2006-12-21 | — | — | WO | claimed |