Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 14/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 12/20 | 0.41 |
| ▸ | PDE4A | P27815 | 7/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28164154 | 0.82 | PDE4B (0.43) | PDE4DPDE4BPDE4APDE4CRIPK1 | |
| SCHEMBL6877898 | 0.82 | PDE4B (0.43) | PDE4DPDE4BPDE4APDE4CRIPK1 | |
| SCHEMBL10209543 | 0.80 | SMN1; SMN2 (0.44) | PDE4DPDE4BPDE4APDE4CRIPK1 | |
| SCHEMBL129328 | 0.80 | PDE4D (0.42) | PDE4DPDE4BPDE4APDE4CABCB11 | |
| SCHEMBL18830718 | 0.78 | PDE4B (0.53) | PDE4DPDE4BPDE4APDE4CRIPK1 | |
| SCHEMBL29994875 | 0.78 | PDE4B (0.53) | PDE4DPDE4BPDE4APDE4CRIPK1 | |
| SCHEMBL27756339 | 0.77 | PDE4B (0.42) | PDE4DPDE4BPDE4APDE4CABCB11 | |
| SCHEMBL4594035 | 0.77 | PDE4B (0.45) | PDE4DPDE4BPDE4APDE4CABCB11 | |
| SCHEMBL129155 | 0.77 | RIPK1 (0.39) | PDE4DPDE4BPDE4APDE4CRIPK1 | |
| SCHEMBL8232372 | 0.76 | THRA (0.36) | RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2643000-A2 | THERAPEUTIC PIPERAZINES | Dart Neuroscience (Cayman) Ltd (KY) | 2013-10-02 | — | — | EP | disclosed |
| WO-2012040258-A2 | THERAPEUTIC PIPERAZINES | HELICON THERAPEUTICS, INC. (US) | 2012-03-29 | — | — | WO | disclosed |