Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 3/20 | 0.43 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4593898 | 0.93 | SSTR5 (0.45) | SSTR5SSTR1TP53MAPTNPC1 | |
| SCHEMBL4593662 | 0.92 | NPC1 (0.42) | TP53MAPTNPC1RAB9ANFKB1 | |
| SCHEMBL4593609 | 0.92 | SSTR5 (0.45) | SSTR5SSTR1TP53MAPTNPC1 | |
| SCHEMBL4593978 | 0.88 | MAPT (0.39) | SSTR5SSTR1TP53MAPTNPC1 | |
| SCHEMBL4593325 | 0.87 | SSTR5 (0.46) | SSTR5SSTR1 | |
| SCHEMBL4594394 | 0.85 | SSTR1 (0.39) | SSTR5SSTR1TP53MAPTNPC1 | |
| SCHEMBL4594195 | 0.84 | NPC1 (0.44) | SSTR5TP53MAPTNPC1RAB9A | |
| SCHEMBL4594675 | 0.82 | SSTR5 (0.47) | SSTR5SSTR1TP53MAPTNPC1 | |
| SCHEMBL4593554 | 0.82 | SSTR5 (0.36) | SSTR5SSTR1TP53MAPTNPC1 | |
| SCHEMBL4594161 | 0.81 | NFKB1 (0.38) | TP53MAPTNPC1RAB9AMITF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924579-A2 | BENZOOXAZOLE, OXAZOLOPYRIDINE, BENZOTHIAZOLE AND THIAZOLOPYRIDINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-05-28 | — | — | EP | claimed |
| WO-2007025897-A2 | BENZOOXAZOLE, OXAZOLOPYRIDINE, BENZOTHIAZOLE AND THIAZOLOPYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-03-08 | — | — | WO | claimed |
| EP-1924579-A2 | BENZOOXAZOLE, OXAZOLOPYRIDINE, BENZOTHIAZOLE AND THIAZOLOPYRIDINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007025897-A2 | BENZOOXAZOLE, OXAZOLOPYRIDINE, BENZOTHIAZOLE AND THIAZOLOPYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-03-08 | — | — | WO | disclosed |