Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 2/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | DHFR | P00374 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | PDE5A | O76074 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | PLAT | P00750 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4594393 | 0.89 | SSTR5 (0.32) | SSTR5PDE5ATP53MAPTLMNA | |
| SCHEMBL4594733 | 0.89 | TP53 (0.34) | SSTR5PDE5ATP53MAPTLMNA | |
| SCHEMBL4593975 | 0.87 | PCSK9 (0.40) | MAPK1USP2GAATP53MAPT | |
| SCHEMBL4594240 | 0.84 | SSTR5 (0.36) | SSTR5MAPTLMNAABL1HPGD | |
| SCHEMBL4593786 | 0.83 | SSTR5 (0.35) | SSTR5HRH1DHFRMAPK1USP2 | |
| SCHEMBL4593554 | 0.83 | SSTR5 (0.36) | SSTR5HRH1DHFRMAPK1USP2 | |
| SCHEMBL4593978 | 0.83 | MAPT (0.39) | SSTR5HRH1MAPK1TP53MAPT | |
| SCHEMBL4594897 | 0.81 | HTR2A (0.34) | PLAT | |
| SCHEMBL4593662 | 0.76 | NPC1 (0.42) | USP2GAATP53MAPTHPGD | |
| SCHEMBL4594195 | 0.76 | NPC1 (0.44) | SSTR5USP2GAATP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924579-A2 | BENZOOXAZOLE, OXAZOLOPYRIDINE, BENZOTHIAZOLE AND THIAZOLOPYRIDINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007025897-A2 | BENZOOXAZOLE, OXAZOLOPYRIDINE, BENZOTHIAZOLE AND THIAZOLOPYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-03-08 | — | — | WO | disclosed |