Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
| ▸ | TACR1 | P25103 | 2/20 | 0.33 |
| ▸ | SSTR5 | P35346 | 2/20 | 0.32 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.32 |
| ▸ | PLAT | P00750 | 1/20 | 0.31 |
| ▸ | NMT2 | O60551 | 1/20 | 0.31 |
| ▸ | NMT1 | P30419 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | PDE5A | O76074 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4594393 | 0.92 | SSTR5 (0.32) | TP53MAPTLMNASLC2A1TACR1 | |
| SCHEMBL4594462 | 0.89 | SSTR5 (0.34) | TP53MAPTLMNASSTR5PLAT | |
| SCHEMBL4594240 | 0.87 | SSTR5 (0.36) | MAPTLMNASSTR5SSTR1KCNH2 | |
| SCHEMBL4593662 | 0.86 | NPC1 (0.42) | TP53MAPT | |
| SCHEMBL4594897 | 0.84 | HTR2A (0.34) | PLATNMT2NMT1SLC6A2SLC6A4 | |
| SCHEMBL4594394 | 0.82 | SSTR1 (0.39) | TP53MAPTLMNASLC2A1TACR1 | |
| SCHEMBL4594269 | 0.81 | SSTR5 (0.43) | TP53MAPTSSTR5SSTR1 | |
| SCHEMBL4593898 | 0.81 | SSTR5 (0.45) | TP53MAPTLMNASLC2A1TACR1 | |
| SCHEMBL4594195 | 0.78 | NPC1 (0.44) | TP53MAPTSSTR5 | |
| SCHEMBL4593975 | 0.75 | PCSK9 (0.40) | TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924579-A2 | BENZOOXAZOLE, OXAZOLOPYRIDINE, BENZOTHIAZOLE AND THIAZOLOPYRIDINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007025897-A2 | BENZOOXAZOLE, OXAZOLOPYRIDINE, BENZOTHIAZOLE AND THIAZOLOPYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-03-08 | — | — | WO | disclosed |