Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.34 |
| ▸ | MBTPS1 | Q14703 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | PLAT | P00750 | 1/20 | 0.31 |
| ▸ | NMT1 | P30419 | 2/20 | 0.31 |
| ▸ | NMT2 | O60551 | 1/20 | 0.31 |
| ▸ | ACACB | O00763 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4594509 | 0.86 | NPC1 (0.44) | HTR2AMBTPS1 | |
| SCHEMBL4594393 | 0.84 | SSTR5 (0.32) | SLC6A2SLC6A4SLC6A3KCNH2PLAT | |
| SCHEMBL4594733 | 0.84 | TP53 (0.34) | SLC6A2SLC6A4SLC6A3KCNH2PLAT | |
| SCHEMBL4594462 | 0.81 | SSTR5 (0.34) | PLAT | |
| SCHEMBL4594240 | 0.80 | SSTR5 (0.36) | KCNH2 | |
| SCHEMBL4593487 | 0.80 | TRPV1 (0.38) | HTR2AMBTPS1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4594515 | 0.79 | NPC1 (0.39) | HTR2AMBTPS1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4594161 | 0.79 | NFKB1 (0.38) | HTR2AMBTPS1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4594195 | 0.70 | NPC1 (0.44) | — | |
| SCHEMBL4593662 | 0.70 | NPC1 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924579-A2 | BENZOOXAZOLE, OXAZOLOPYRIDINE, BENZOTHIAZOLE AND THIAZOLOPYRIDINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007025897-A2 | BENZOOXAZOLE, OXAZOLOPYRIDINE, BENZOTHIAZOLE AND THIAZOLOPYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-03-08 | — | — | WO | disclosed |