SCHEMBL459453

SCHEMBL459453

CCC(CO)Nc1ccc(N)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FYN P06241 2/20 0.52
SMN1; SMN2 Q16637 3/20 0.42
ALDH1A1 P00352 3/20 0.42
TDP1 Q9NUW8 2/20 0.42
TP53 P04637 2/20 0.42
HSP90AA1 P07900 1/20 0.42
CYP3A4 P08684 1/20 0.42
THRB P10828 1/20 0.42
ALOX15 P16050 1/20 0.42
TSHR P16473 1/20 0.42
CASP1 P29466 1/20 0.42
HIF1A Q16665 1/20 0.42
HSD17B10 Q99714 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
KCNH3 Q9ULD8 1/20 0.41
CDK2 P24941 4/20 0.39
CCNE1 P24864 1/20 0.39
LMNA P02545 2/20 0.39
KDM4E B2RXH2 2/20 0.39
CNR1 P21554 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6671578 1.00 FYN (0.52) FYNSMN1; SMN2ALDH1A1TDP1TP53
SCHEMBL3860929 0.88 MAPT (0.41) FYNSMN1; SMN2ALDH1A1TDP1TP53
SCHEMBL21799857 0.88 ALDH1A1 (0.48) FYNSMN1; SMN2ALDH1A1TDP1TP53
Hydrochloric Acid SCHEMBL3857260 0.86 MAPT (0.40) FYNSMN1; SMN2ALDH1A1TDP1TP53
SCHEMBL25560558 0.85 TLR8 (0.45) FYNSMN1; SMN2ALDH1A1TDP1TP53
SCHEMBL6838626 0.81 MAPT (0.36) FYNALDH1A1TDP1CYP3A4L3MBTL1
SCHEMBL17604111 0.81 HTT (0.47) SMN1; SMN2ALDH1A1TDP1TP53HSP90AA1
SCHEMBL21799960 0.81 ALDH1A1 (0.42) FYNSMN1; SMN2ALDH1A1TDP1TP53
SCHEMBL2937099 0.80 KCNH3 (0.54) SMN1; SMN2ALDH1A1TDP1TP53HSP90AA1
SCHEMBL20362192 0.80 KCNH3 (0.54) SMN1; SMN2ALDH1A1TDP1TP53HSP90AA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 529 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0850636-B2 Composition for the oxidative dyeing of keratinic fibres and dyeing process using this composition OREAL (FR) 2013-11-20 EP claimed
CN-101444460-B Oxidation dye composition, oxidation dyeing process and use OU LAIYA 2013-08-14 CN claimed
EP-0850637-B2 Composition for the oxidative dyeing of keratinic fibres and dyeing process using this composition OREAL (FR) 2010-11-10 EP claimed
EP-1047376-B2 KERATINOUS FIBRE DYEING COMPOSITION CONTAINING A LACCASE AND DYEING METHOD USING SAME OREAL (FR) 2009-03-18 EP claimed
EP-1433470-B1 Composition for dyeing keratinous fibres HENKEL KGAA (DE) 2008-03-26 EP claimed
EP-0852135-B2 Oxidative dyeing composition for keratin fibres and dyeing method employing it OREAL (FR) 2008-03-19 EP claimed
WO-2007071686-A1 COMPOSITION FOR DYEING KERATIN FIBRES WITH A TETRAAZAPENTAMETHINE CATIONIC DIRECT DYE, AN OXIDATION BASE AND A PARTICULAR COUPLER L'ORÉAL (FR) 2007-06-28 WO claimed
US-7141078-B2 Oxidation dyeing composition for keratinous fiber and dyeing method using same L′Oreal (FR) 2006-11-28 US claimed
US-7141079-B2 Oxidation dyeing composition for keratinous fibers and dyeing method using same L′Oreal (FR) 2006-11-28 US claimed
EP-1274393-B1 OXIDATION DYEING COMPOSITION FOR KERATINOUS FIBRES AND METHOD USING SAME OREAL (FR) 2006-07-05 EP claimed
CN-1242699-A Oxidation dyeing composition for keratin fibres and dyeing method using said composition OREAL (FR) 2000-01-26 CN claimed
CN-1241137-A Composition for the oxidation dyeing of keratin fibres and dyeing process using this composition OREAL (FR) 2000-01-12 CN claimed
CN-1239422-A Oxidation dyeing compsn. for keratin fibres and dyeing method of using same OREAL (FR) 1999-12-22 CN claimed
US-6001135-A READY-TO-USE OXIDATION DYEING FOR HUMAN HAIR L'OREAL (FR) 1999-12-14 US claimed
US-5993490-A Composition for the oxidation dyeing of keratin fibers containing a cationic direct dye and dyeing process using this composition L'OREAL (FR) 1999-11-30 US claimed
EP-0850638-B1 Oxidative dye composition for keratinic fibres and dyeing process using this composition OREAL (FR) 1999-09-01 EP claimed
US-5919273-A READY-TO-USE COMPOSITION DYES HAIR GIVING UNIFORM COLOR; OXIDATION BASE IN COMBINATION WITH A SUBSTITUTED META-AMINOPHENOL COUPLER, CATIONIC DIRECT DYE AND OXIDIZING AGENT; MULTICOMPARTMENT DYE KIT L'OREAL (FR) 1999-07-06 US claimed
EP-0850637-B1 Composition for the oxidative dyeing of keratinic fibres and dyeing process using this composition OREAL (FR) 1999-06-02 EP claimed
EP-0850636-B1 Composition for the oxidative dyeing of keratinic fibres and dyeing process using this composition OREAL (FR) 1999-05-06 EP claimed
EP-0852135-B1 Oxidative dyeing composition for keratin fibres and dyeing method employing it OREAL (FR) 1999-04-28 EP claimed