Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.35 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4593612 | 0.90 | LMNA (0.42) | LMNAALDH1A1SMN1; SMN2MAPTMEN1 | |
| SCHEMBL4595070 | 0.84 | LMNA (0.42) | LMNAALDH1A1SMN1; SMN2MAPTMEN1 | |
| SCHEMBL1306910 | 0.72 | MEN1 (0.45) | LMNAALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL4595102 | 0.69 | LMNA (0.44) | LMNAALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL1306946 | 0.61 | LMNA (0.48) | LMNAALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL12576936 | 0.57 | AVPR1A (0.74) | LMNAALDH1A1MEN1KMT2AHTT | |
| SCHEMBL2895098 | 0.56 | ALDH1A1 (0.73) | LMNAALDH1A1MEN1KMT2ANPSR1 | |
| SCHEMBL3455628 | 0.56 | ALDH1A1 (0.69) | LMNAALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL3455001 | 0.56 | MEN1 (0.54) | LMNAALDH1A1SMN1; SMN2MAPTMEN1 | |
| SCHEMBL3456297 | 0.56 | MEN1 (0.54) | LMNAALDH1A1SMN1; SMN2MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945207-A2 | PHARMACEUTICAL USE OF SUBSTITUTED AMIDES | Transtech Pharma, Inc. (US) | 2008-07-23 | — | — | EP | disclosed |
| WO-2007051811-A2 | PHARMACEUTICAL USE OF SUBSTITUTED AMIDES | TRANSTECH PHARMA (US) | 2007-05-10 | — | — | WO | disclosed |