Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of Choline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.61 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.44 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.38 |
| ▸ | ENPEP | Q07075 | 4/20 | 0.37 |
| ▸ | SLC1A1 | P43005 | 4/20 | 0.35 |
| ▸ | SLC1A3 | P43003 | 4/20 | 0.34 |
| ▸ | SLC1A2 | P43004 | 4/20 | 0.34 |
| ▸ | GRIK1 | P39086 | 3/20 | 0.33 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.33 |
| ▸ | GRM8 | O00222 | 1/20 | 0.33 |
| ▸ | GRM6 | O15303 | 1/20 | 0.33 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.33 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.33 |
| ▸ | GSR | P00390 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Choline SCHEMBL4594634 | 1.00 | PTGS1 (0.61) | PTGS1SLC7A11MEN1LMNAKMT2A | |
| Choline SCHEMBL8135839 | 0.98 | PTGS1 (0.59) | PTGS1SLC7A11MEN1LMNAKMT2A | |
| Choline SCHEMBL8135850 | 0.98 | PTGS1 (0.59) | PTGS1SLC7A11MEN1LMNAKMT2A | |
| Choline SCHEMBL8135842 | 0.98 | PTGS1 (0.59) | PTGS1SLC7A11MEN1LMNAKMT2A | |
| Cadaverine Tartrate SCHEMBL27758938 | 0.87 | PTGS1 (0.47) | PTGS1SLC7A11MEN1LMNAKMT2A | |
| Choline SCHEMBL1683106 | 0.84 | KMT2A (0.48) | PTGS1SLC7A11MEN1LMNAKMT2A | |
| Choline SCHEMBL1683101 | 0.84 | KMT2A (0.48) | PTGS1SLC7A11MEN1LMNAKMT2A | |
| Cysteine SCHEMBL28102468 | 0.83 | PTGS1 (0.80) | PTGS1SLC7A11KMT2ASLC7A5ENPEP | |
| Cysteine SCHEMBL28102471 | 0.83 | PTGS1 (0.80) | PTGS1SLC7A11KMT2ASLC7A5ENPEP | |
| Choline SCHEMBL8217649 | 0.83 | LMNA (0.43) | PTGS1SLC7A11MEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114621984-B | Method for synthesizing 1, 5-pentanediamine by using ionic liquid to strengthen lysine decarboxylase | 中国科学院过程工程研究所 | 2025-01-28 | — | — | CN | claimed |
| CN-114621984-A | Method for synthesizing 1, 5-pentanediamine by strengthening lysine decarboxylase through ionic liquid | 中国科学院过程工程研究所 | 2022-06-14 | — | — | CN | claimed |
| CN-114426992-A | Amino functionalized ionic liquid reinforced CO2Biotransformation process | 中国科学院过程工程研究所 | 2022-05-03 | — | — | CN | claimed |
| CN-114621984-B | Method for synthesizing 1, 5-pentanediamine by using ionic liquid to strengthen lysine decarboxylase | 中国科学院过程工程研究所 | 2025-01-28 | — | — | CN | disclosed |
| CN-114621984-A | Method for synthesizing 1, 5-pentanediamine by strengthening lysine decarboxylase through ionic liquid | 中国科学院过程工程研究所 | 2022-06-14 | — | — | CN | disclosed |
| CN-114426992-A | Amino functionalized ionic liquid reinforced CO2Biotransformation process | 中国科学院过程工程研究所 | 2022-05-03 | — | — | CN | disclosed |
| EP-1968650-A2 | COMPOUNDS FOR DELIVERING AMINO ACIDS OR PEPTIDES WITH ANTIOXIDANT ACTIVITY INTO MITOCHONDRIA AND USE THEREOF | University of Rochester (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007076323-A2 | COMPOUNDS FOR DELIVERING AMINO ACIDS OR PEPTIDES WITH ANTIOXIDANT ACTIVITY INTO MITOCHONDRIA AND USE THEREOF | UNIVERSITY OF ROCHESTER (US) | 2007-07-05 | — | — | WO | disclosed |