Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of Choline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.48 |
| ▸ | SLC1A1 | P43005 | 5/20 | 0.42 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.38 |
| ▸ | SLC1A3 | P43003 | 5/20 | 0.36 |
| ▸ | SLC1A2 | P43004 | 5/20 | 0.36 |
| ▸ | GRIK1 | P39086 | 4/20 | 0.35 |
| ▸ | GRIK2 | Q13002 | 3/20 | 0.35 |
| ▸ | GRM8 | O00222 | 1/20 | 0.35 |
| ▸ | GRM6 | O15303 | 1/20 | 0.35 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.35 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.35 |
| ▸ | GSR | P00390 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Choline SCHEMBL1683101 | 1.00 | KMT2A (0.48) | KMT2AMEN1LMNACYP3A4SLC5A7 | |
| Scyllitol SCHEMBL6670313 | 0.87 | MEN1 (0.36) | KMT2AMEN1LMNACYP3A4SLC5A7 | |
| Inositol SCHEMBL6670311 | 0.87 | MEN1 (0.36) | KMT2AMEN1LMNACYP3A4SLC5A7 | |
| Choline SCHEMBL22345960 | 0.85 | LMNA (0.55) | KMT2AMEN1LMNACYP3A4SLC5A7 | |
| Aspartic Acid SCHEMBL14742424 | 0.84 | MEN1 (0.44) | KMT2AMEN1LMNACYP3A4SLC5A7 | |
| Aspartic Acid SCHEMBL14742425 | 0.84 | MEN1 (0.44) | KMT2AMEN1LMNACYP3A4SLC5A7 | |
| Choline SCHEMBL4594631 | 0.84 | PTGS1 (0.61) | KMT2AMEN1LMNACYP3A4SLC5A7 | |
| Choline SCHEMBL4594634 | 0.84 | PTGS1 (0.61) | KMT2AMEN1LMNACYP3A4SLC5A7 | |
| Choline SCHEMBL14742052 | 0.83 | LMNA (0.52) | KMT2AMEN1LMNACYP3A4SLC5A7 | |
| Choline SCHEMBL28946100 | 0.83 | CYP3A4 (0.59) | KMT2AMEN1LMNACYP3A4SLC5A7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117327137-B | Method for separating cholic acid and deoxycholic acid by using biocompatible two-phase system | 浙江大学 | 2025-04-29 | — | — | CN | claimed |
| CN-117327137-A | Method for separating cholic acid and deoxycholic acid by using biocompatible two-phase system | 浙江大学 | 2024-01-02 | — | — | CN | claimed |
| CN-114621984-A | Method for synthesizing 1, 5-pentanediamine by strengthening lysine decarboxylase through ionic liquid | 中国科学院过程工程研究所 | 2022-06-14 | — | — | CN | claimed |
| CN-114426992-A | Amino functionalized ionic liquid reinforced CO2Biotransformation process | 中国科学院过程工程研究所 | 2022-05-03 | — | — | CN | claimed |
| CN-108794652-B | Chitin integrated production system and processing method thereof | 中国科学院过程工程研究所 | 2021-02-05 | — | — | CN | claimed |
| CN-108794652-A | A kind of chitin integraterd manufacturing system and its processing method | 中国科学院过程工程研究所 | 2018-11-13 | — | — | CN | claimed |
| CN-107778347-A | It is a kind of using amino acid ion liquid from silkworm chrysalis separated and dissolved pupa albumen method | 中国科学院过程工程研究所 | 2018-03-09 | — | — | CN | claimed |
| CN-107312109-A | Chitin separating and extracting process in a kind of shrimp and crab shells based on degradable ionic liquid | 中国科学院过程工程研究所 | 2017-11-03 | — | — | CN | claimed |
| EP-2303019-A1 | (6S)-5-METHYLTETRAHYDROFOLIC ACID FOR THERAPY OF TISSUE INJURY | Iskandar, Bermans S. (US) | 2011-04-06 | — | — | EP | claimed |
| WO-2009158430-A1 | (6S)-5-METHYLTETRAHYDROFOLIC ACID FOR THERAPY OF TISSUE INJURY | ISKANDAR BERMANS S (US) | 2009-12-30 | — | — | WO | claimed |
| CN-117327137-B | Method for separating cholic acid and deoxycholic acid by using biocompatible two-phase system | 浙江大学 | 2025-04-29 | — | — | CN | disclosed |
| WO-2025039592-A1 | METHOD FOR SEPARATING CHOLIC ACID AND DEOXYCHOLIC ACID BY BIOCOMPATIBLE TWO-PHASE SYSTEM | 浙江大学 | 2025-02-27 | — | — | WO | disclosed |
| CN-114621984-B | Method for synthesizing 1, 5-pentanediamine by using ionic liquid to strengthen lysine decarboxylase | 中国科学院过程工程研究所 | 2025-01-28 | — | — | CN | disclosed |
| CN-117700572-A | Method for extracting crude polysaccharide from algae residue by choline amino acid ionic liquid hydrolysis | 昆明理工大学 | 2024-03-15 | — | — | CN | disclosed |
| CN-117327137-A | Method for separating cholic acid and deoxycholic acid by using biocompatible two-phase system | 浙江大学 | 2024-01-02 | — | — | CN | disclosed |
| CN-107778347-A | It is a kind of using amino acid ion liquid from silkworm chrysalis separated and dissolved pupa albumen method | 中国科学院过程工程研究所 | 2018-03-09 | — | — | CN | disclosed |
| CN-107312109-A | Chitin separating and extracting process in a kind of shrimp and crab shells based on degradable ionic liquid | 中国科学院过程工程研究所 | 2017-11-03 | — | — | CN | disclosed |
| US-20110171134-A1 | (6S)-5-METHYLTETRAHYDROFOLIC ACID FOR THERAPY OF TISSUE INJURY | ISKANDAR BERMANS J | 2011-07-14 | — | — | US | disclosed |
| EP-2303019-A1 | (6S)-5-METHYLTETRAHYDROFOLIC ACID FOR THERAPY OF TISSUE INJURY | Iskandar, Bermans S. (US) | 2011-04-06 | — | — | EP | disclosed |
| WO-2009158430-A1 | (6S)-5-METHYLTETRAHYDROFOLIC ACID FOR THERAPY OF TISSUE INJURY | ISKANDAR BERMANS S (US) | 2009-12-30 | — | — | WO | disclosed |