Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 9/20 | 0.60 |
| ▸ | KDR | P35968 | 9/20 | 0.50 |
| ▸ | EGFR | P00533 | 5/20 | 0.50 |
| ▸ | RET | P07949 | 2/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.49 |
| ▸ | GAK | O14976 | 1/20 | 0.48 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.48 |
| ▸ | STK10 | O94804 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
| ▸ | JAK3 | P52333 | 1/20 | 0.48 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.48 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.48 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.48 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.48 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.48 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4595269 | 0.92 | AURKA (0.58) | AURKAKDREGFRRETLCK | |
| SCHEMBL4595690 | 0.83 | AURKA (0.63) | AURKAKDREGFRAURKBJAK3 | |
| SCHEMBL4594818 | 0.81 | AURKA (0.76) | AURKAKDREGFRLCKAURKB | |
| SCHEMBL14095616 | 0.79 | AURKA (0.57) | AURKAKDREGFRAURKBJAK3 | |
| SCHEMBL14095613 | 0.77 | AURKA (0.60) | AURKAKDREGFRAURKBJAK3 | |
| SCHEMBL14095610 | 0.77 | AURKA (0.61) | AURKAKDREGFRAURKBJAK3 | |
| SCHEMBL14421354 | 0.74 | AURKA (0.52) | AURKAKDREGFRRETLCK | |
| SCHEMBL5027804 | 0.72 | AURKA (0.74) | AURKAKDREGFRAURKBFLT3 | |
| SCHEMBL23075114 | 0.72 | KDR (0.69) | KDREGFR | |
| SCHEMBL4760833 | 0.71 | KDR (0.69) | AURKAKDREGFRRETLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948651-A1 | THIAZOLE ANALOGUES AND USES THEREOF | 4SC AG (DE) | 2008-07-30 | — | — | EP | disclosed |
| US-20070149523-A1 | Thiazole Analogues and Uses Thereof | 4SC AG (DE) | 2007-06-28 | — | — | US | disclosed |
| US-20070149523-A1 | Thiazole Analogues and Uses Thereof | 4SC AG (DE) | 2007-06-28 | — | — | US | disclosed |
| US-20070149523-A1 | Thiazole Analogues and Uses Thereof | 4SC AG (DE) | 2007-06-28 | — | — | US | disclosed |
| WO-2007054357-A1 | THIAZOLE ANALOGUES AND USES THEREOF | 4SC AG (DE) | 2007-05-18 | — | — | WO | disclosed |
| WO-2007054357-A1 | THIAZOLE ANALOGUES AND USES THEREOF | 4SC AG (DE) | 2007-05-18 | — | — | WO | disclosed |
| EP-1785420-A1 | Thiazole analogues and uses thereof | 4SC AG (DE) | 2007-05-16 | — | — | EP | disclosed |
| EP-1785420-A1 | Thiazole analogues and uses thereof | 4SC AG (DE) | 2007-05-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070149523-A1 | Thiazole Analogues and Uses Thereof | NR3C2, SLC26A4, CLIC4 | AURKA 2397/4885KDR 1073/4885EGFR 186/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.