Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GMNN | O75496 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | MMP8 | P22894 | 1/20 | 0.34 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 2/20 | 0.34 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | MMP2 | P08253 | 2/20 | 0.34 |
| ▸ | CA9 | Q16790 | 2/20 | 0.34 |
| ▸ | CPB2 | Q96IY4 | 2/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1583311 | 0.74 | KDM4E (0.43) | SMN1; SMN2KDM4ELMNAALDH1A1EPHX2 | |
| SCHEMBL4595419 | 0.72 | CA12 (0.40) | SMN1; SMN2ALDH1A1CA12CA1CA2 | |
| SCHEMBL2322983 | 0.71 | KDM4E (0.39) | SMN1; SMN2KDM4ELMNAALDH1A1EPHX2 | |
| SCHEMBL490640 | 0.71 | CTSK (0.48) | EPHX1 | |
| SCHEMBL1147462 | 0.71 | CTSK (0.48) | EPHX1 | |
| SCHEMBL1069360 | 0.69 | OR51E2 (0.33) | LMNAMMP1 | |
| SCHEMBL3586116 | 0.69 | TP53 (0.50) | TP53SMN1; SMN2KDM4EGMNNLMNA | |
| SCHEMBL1862557 | 0.69 | CA12 (0.34) | SMN1; SMN2ALDH1A1MMP1MMP8ADAM17 | |
| SCHEMBL6938204 | 0.69 | CA12 (0.34) | SMN1; SMN2ALDH1A1MMP1MMP8ADAM17 | |
| SCHEMBL3579526 | 0.67 | TP53 (0.47) | TP53SMN1; SMN2KDM4EGMNNLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874768-A2 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006113837-A2 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-26 | — | — | WO | disclosed |