Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 14/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 14/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 10/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 8/20 | 0.48 |
| ▸ | PI4KB | Q9UBF8 | 7/20 | 0.47 |
| ▸ | PIK3C3 | Q8NEB9 | 3/20 | 0.47 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.47 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.47 |
| ▸ | PI4KA | P42356 | 1/20 | 0.47 |
| ▸ | PRKDC | P78527 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL436324 | 0.93 | PIK3CD (0.55) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| Hydrochloric Acid SCHEMBL435504 | 0.92 | PIK3CD (0.54) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL435741 | 0.80 | PIK3CD (0.54) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL434648 | 0.77 | PIK3CD (0.65) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL4222907 | 0.75 | PIK3CD (0.56) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL4222887 | 0.75 | PIK3CD (0.56) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL48762 | 0.75 | PIK3CD (0.67) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL21301610 | 0.74 | PIK3CD (0.56) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL30792275 | 0.74 | PIK3CD (0.55) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL14384982 | 0.74 | PIK3CD (0.54) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8153389-B2 | Methods for the identification of PI3K interacting molecules and for the purification of PI3K | Cellzone AG (DE) | 2012-04-10 | — | — | US | disclosed |
| EP-2410062-A1 | Selectivity profiling of PI3K interacting molecules against multiple targets | CELLZOME AG (DE) | 2012-01-25 | — | — | EP | disclosed |
| EP-2245181-B1 | SELECTIVITY PROFILING OF PI3K INTERACTING MOLECULES AGAINST MULTIPLE TARGETS | CELLZOME AG (DE) | 2011-10-12 | — | — | EP | disclosed |
| US-20110111972-A1 | SELECTIVITY PROFILING OF PI3K INTERACTING MOLECULES AGAINST MULTIPLE TARGETS | CELLZOME AG (DE) | 2011-05-12 | — | — | US | disclosed |