Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 14/20 | 0.55 |
| ▸ | PIK3CG | P48736 | 14/20 | 0.55 |
| ▸ | PIK3CA | P42336 | 10/20 | 0.55 |
| ▸ | PIK3CB | P42338 | 8/20 | 0.55 |
| ▸ | PI4KB | Q9UBF8 | 7/20 | 0.51 |
| ▸ | PIK3C3 | Q8NEB9 | 3/20 | 0.51 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.51 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.51 |
| ▸ | PI4KA | P42356 | 1/20 | 0.51 |
| ▸ | PRKDC | P78527 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL435504 | 0.99 | PIK3CD (0.54) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| Hydrochlorthiazide SCHEMBL459506 | 0.93 | PIK3CD (0.48) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL435741 | 0.86 | PIK3CD (0.54) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL434648 | 0.83 | PIK3CD (0.65) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL4222907 | 0.81 | PIK3CD (0.56) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL4222887 | 0.81 | PIK3CD (0.56) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL48762 | 0.81 | PIK3CD (0.67) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL21301610 | 0.80 | PIK3CD (0.56) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL14384982 | 0.80 | PIK3CD (0.54) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| Hydrochloric Acid SCHEMBL4707313 | 0.80 | TGFBR1 (0.37) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2410062-A1 | Selectivity profiling of PI3K interacting molecules against multiple targets | CELLZOME AG (DE) | 2012-01-25 | — | — | EP | claimed |
| EP-2245181-B1 | SELECTIVITY PROFILING OF PI3K INTERACTING MOLECULES AGAINST MULTIPLE TARGETS | CELLZOME AG (DE) | 2011-10-12 | — | — | EP | claimed |
| EP-1887359-B1 | Methods for the identification of PI3K interacting molecules and for the purification of PI3K | CELLZOME AG (DE) | 2008-11-12 | — | — | EP | claimed |
| US-11254671-B2 | Chemical compounds | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2022-02-22 | — | — | US | disclosed |
| US-20210163472-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2021-06-03 | — | — | US | disclosed |
| US-8153389-B2 | Methods for the identification of PI3K interacting molecules and for the purification of PI3K | Cellzone AG (DE) | 2012-04-10 | — | — | US | disclosed |
| US-8153389-B2 | Methods for the identification of PI3K interacting molecules and for the purification of PI3K | Cellzone AG (DE) | 2012-04-10 | — | — | US | disclosed |
| EP-2410062-A1 | Selectivity profiling of PI3K interacting molecules against multiple targets | CELLZOME AG (DE) | 2012-01-25 | — | — | EP | disclosed |
| EP-2410062-A1 | Selectivity profiling of PI3K interacting molecules against multiple targets | CELLZOME AG (DE) | 2012-01-25 | — | — | EP | disclosed |
| EP-2245181-B1 | SELECTIVITY PROFILING OF PI3K INTERACTING MOLECULES AGAINST MULTIPLE TARGETS | CELLZOME AG (DE) | 2011-10-12 | — | — | EP | disclosed |
| EP-2245181-B1 | SELECTIVITY PROFILING OF PI3K INTERACTING MOLECULES AGAINST MULTIPLE TARGETS | CELLZOME AG (DE) | 2011-10-12 | — | — | EP | disclosed |
| US-20110111972-A1 | SELECTIVITY PROFILING OF PI3K INTERACTING MOLECULES AGAINST MULTIPLE TARGETS | CELLZOME AG (DE) | 2011-05-12 | — | — | US | disclosed |
| US-20110111972-A1 | SELECTIVITY PROFILING OF PI3K INTERACTING MOLECULES AGAINST MULTIPLE TARGETS | CELLZOME AG (DE) | 2011-05-12 | — | — | US | disclosed |
| EP-2245181-A1 | SELECTIVITY PROFILING OF PI3K INTERACTING MOLECULES AGAINST MULTIPLE TARGETS | CELLZOME AG (DE) | 2010-11-03 | — | — | EP | disclosed |
| US-20100055711-A1 | METHODS FOR THE IDENTIFICATION OF PI3K INTERACTING MOLECULES AND FOR THE PURIFICATION OF PI3K | CELLZOME AG (DE) | 2010-03-04 | — | — | US | disclosed |
| US-20100055711-A1 | METHODS FOR THE IDENTIFICATION OF PI3K INTERACTING MOLECULES AND FOR THE PURIFICATION OF PI3K | CELLZOME AG (DE) | 2010-03-04 | — | — | US | disclosed |
| WO-2009098021-A1 | SELECTIVITY PROFILING OF PI3K INTERACTING MOLECULES AGAINST MULTIPLE TARGETS | CELLZOME AG (DE) | 2009-08-13 | — | — | WO | disclosed |
| EP-1887359-A1 | Methods for the identification of PI3K interacting molecules and for the purification of PI3K | CELLZOME AG (DE) | 2008-02-13 | — | — | EP | disclosed |
| WO-2008015013-A1 | METHODS FOR THE IDENTIFICATION OF PI3K INTERACTING MOLECULES AND FOR THE PURIFICATION OF PI3K | CELLZOME AG (DE) | 2008-02-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210163472-A1 | CHEMICAL COMPOUNDS | MTOR, RICTOR, RPTOR | PIK3CD 98/4885PIK3CG 135/4885PIK3CA 60/4885 |
| US-11254671-B2 | Chemical compounds | MTOR, RICTOR, RPTOR | PIK3CD 98/4885PIK3CG 135/4885PIK3CA 60/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.