Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HAO1 | Q9UJM8 | 6/20 | 0.50 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 2/20 | 0.36 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30689318 | 0.83 | FFAR4 (0.56) | FFAR4SCN9ALTA4HPTGS2GRM5 | |
| SCHEMBL4458288 | 0.76 | FFAR4 (0.53) | HAO1FFAR4GRM5 | |
| SCHEMBL22061563 | 0.74 | KDM4E (0.48) | FFAR4LTA4HPTGS2GRM5 | |
| SCHEMBL18984715 | 0.73 | MAP4K4 (0.50) | FFAR4FFAR1LTA4HPTGS2GRM5 | |
| SCHEMBL6369908 | 0.72 | APP (0.60) | HAO1FFAR4FFAR1GRM5 | |
| SCHEMBL29605037 | 0.71 | SCN9A (0.56) | FFAR4SCN9ALTA4HPTGS2 | |
| SCHEMBL15954253 | 0.71 | SCN9A (0.56) | FFAR4SCN9ALTA4HPTGS2 | |
| SCHEMBL22411061 | 0.71 | FFAR4 (0.45) | FFAR4SCN9ALTA4HPTGS2 | |
| SCHEMBL9368339 | 0.71 | HAO1 (0.45) | HAO1FFAR4LTA4HPTGS2GRM5 | |
| SCHEMBL13085922 | 0.70 | APP (0.57) | HAO1FFAR1LTA4HGRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874724-A2 | PHENYL ETHYNE COMPOUNDS | Merck & Co., Inc. (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006115895-A2 | PHENYL ETHYNE COMPOUNDS | MERCK & CO., INC. (US) | 2006-11-02 | — | — | WO | disclosed |