Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HAO1 | Q9UJM8 | 4/20 | 0.45 |
| ▸ | TLR4 | O00206 | 1/20 | 0.45 |
| ▸ | TLR2 | O60603 | 1/20 | 0.45 |
| ▸ | GRM5 | P41594 | 4/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.39 |
| ▸ | HBB | P68871 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | GPR39 | O43194 | 1/20 | 0.38 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.37 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.37 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9049445 | 0.81 | TLR4 (0.47) | HAO1TLR4TLR2GRM5FFAR4 | |
| SCHEMBL9050229 | 0.81 | TLR4 (0.42) | HAO1TLR4TLR2GRM5FFAR4 | |
| SCHEMBL29612417 | 0.80 | TLR4 (0.56) | TLR4TLR2GRM5FFAR4MAP4K4 | |
| SCHEMBL12129555 | 0.80 | TLR4 (0.56) | TLR4TLR2GRM5FFAR4MAP4K4 | |
| SCHEMBL9542091 | 0.79 | HAO1 (0.52) | HAO1MEN1ALDH1A1KMT2ALTA4H | |
| SCHEMBL9118677 | 0.78 | TLR4 (0.42) | TLR4TLR2GRM5FFAR4MAP4K4 | |
| SCHEMBL15602369 | 0.78 | TLR4 (0.55) | TLR4TLR2GRM5FFAR4MAP4K4 | |
| SCHEMBL8559018 | 0.76 | LMNA (0.50) | TLR4TLR2GRM5FFAR4MAP4K4 | |
| SCHEMBL60734 | 0.76 | MAOB (0.58) | TLR4TLR2GRM5FFAR4MAP4K4 | |
| SCHEMBL29947784 | 0.76 | MAOB (0.58) | TLR4TLR2GRM5FFAR4MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0540673-A4 | — | — | 1994-04-27 | — | — | EP | disclosed |
| EP-0540673-A1 | ACETYLENE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY. | ABBOTT LAB (US) | 1993-05-12 | — | — | EP | disclosed |
| WO-1992001682-A1 | ACETYLENE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY | ABBOTT LABORATORIES (US) | 1992-02-06 | — | — | WO | disclosed |