Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | TLR4 | O00206 | 1/20 | 0.47 |
| ▸ | TLR2 | O60603 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CCR1 | P32246 | 1/20 | 0.46 |
| ▸ | CCR5 | P51681 | 1/20 | 0.46 |
| ▸ | CCR8 | P51685 | 1/20 | 0.46 |
| ▸ | METAP1 | P53582 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.46 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12129555 | 0.91 | TLR4 (0.56) | KDM4ETLR4TLR2PTGS2LTA4H | |
| SCHEMBL29612417 | 0.91 | TLR4 (0.56) | KDM4ETLR4TLR2PTGS2LTA4H | |
| SCHEMBL15602369 | 0.89 | TLR4 (0.55) | KDM4ETLR4TLR2PTGS2LTA4H | |
| SCHEMBL11143982 | 0.88 | PTGS2 (0.57) | KDM4ETLR4TLR2PTGS2LTA4H | |
| SCHEMBL29610302 | 0.86 | LOXL2 (0.52) | KDM4ETLR4TLR2PTGS2LTA4H | |
| SCHEMBL147539 | 0.86 | LOXL2 (0.52) | KDM4ETLR4TLR2PTGS2LTA4H | |
| SCHEMBL5346384 | 0.86 | DHODH (0.44) | KDM4ETLR4TLR2PTGS2LTA4H | |
| SCHEMBL30689318 | 0.86 | FFAR4 (0.56) | KDM4ETLR4TLR2PTGS2LTA4H | |
| SCHEMBL409030 | 0.85 | KDM4E (0.55) | KDM4ETLR4TLR2PTGS2LTA4H | |
| SCHEMBL8510667 | 0.84 | LTA4H (0.50) | KDM4ETLR4TLR2PTGS2LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210309610-A1 | NLRX1 LIGANDS | LANDOS BIOPHARMA, INC. (US) | 2021-10-07 | — | — | US | disclosed |
| US-11066364-B2 | NLRX1 ligands | LANDOS BIOPHARMA, INC. (US) | 2021-07-20 | — | — | US | disclosed |
| US-20200255378-A1 | NLRX1 LIGANDS | LANDOS BIOPHARMA, INC. (US) | 2020-08-13 | — | — | US | disclosed |
| US-10676436-B2 | NLRX1 ligands | LANDOS BIOPHARMA, INC. (US) | 2020-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210309610-A1 | NLRX1 LIGANDS | NLRP1, NLRP3, NOD1 | KDM4E 3352/4885TLR4 5/4885TLR2 22/4885 |
| US-20200255378-A1 | NLRX1 LIGANDS | NLRP1, NLRP3, NOD1 | KDM4E 3352/4885TLR4 5/4885TLR2 22/4885 |
| US-11066364-B2 | NLRX1 ligands | NLRP1, NLRP3, NOD1 | KDM4E 3352/4885TLR4 5/4885TLR2 22/4885 |
| US-10676436-B2 | NLRX1 ligands | NLRP1, NLRP3, NOD1 | KDM4E 3352/4885TLR4 5/4885TLR2 22/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.