Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 4/20 | 0.51 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.51 |
| ▸ | DHODH | Q02127 | 12/20 | 0.46 |
| ▸ | AURKA | O14965 | 2/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ASPH | Q12797 | 1/20 | 0.36 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14220102 | 0.88 | MAP2K1 (0.48) | MAP2K1MAP2K2DHODHAURKAMAPK8 | |
| SCHEMBL14222835 | 0.88 | MAP2K1 (0.48) | MAP2K1MAP2K2DHODHAURKAMAPK8 | |
| SCHEMBL14219693 | 0.84 | DHODH (0.41) | MAP2K1MAP2K2DHODHAURKAMAPK8 | |
| SCHEMBL4595156 | 0.81 | DHODH (0.56) | MAP2K1MAP2K2DHODH | |
| SCHEMBL14219691 | 0.81 | DHODH (0.44) | MAP2K1DHODHAURKAMAPK8AURKB | |
| SCHEMBL14219677 | 0.81 | DHODH (0.39) | MAP2K1MAP2K2DHODHAURKAMAPK8 | |
| SCHEMBL14219621 | 0.80 | MAP2K1 (0.48) | MAP2K1MAP2K2DHODH | |
| SCHEMBL14222838 | 0.80 | MAP2K1 (0.57) | MAP2K1MAP2K2DHODH | |
| SCHEMBL14222837 | 0.79 | DHODH (0.54) | MAP2K1MAP2K2DHODH | |
| SCHEMBL14219608 | 0.79 | DHODH (0.54) | MAP2K1MAP2K2DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008041088-A2 | N-HYDROXY BENZAMIDES WITH ANTITUMOR ACTIVITY | EOS (ETHICAL ONCOLOGY SCIENCE) S.P.A. (IT) | 2008-04-10 | — | — | WO | disclosed |
| EP-1908751-A1 | N-hydroxy benzamides with antitumour activity | EOS S.p.A. (IT) | 2008-04-09 | — | — | EP | disclosed |