Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 8/20 | 0.63 |
| ▸ | MAPT | P10636 | 8/20 | 0.63 |
| ▸ | GAA | P10253 | 7/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 7/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | TP53 | P04637 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.49 |
| ▸ | DHODH | Q02127 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12174565 | 0.85 | MAPT (0.47) | PTGDR2MAPTGAASMN1; SMN2MEN1 | |
| SCHEMBL28250062 | 0.81 | PTGDR2 (0.68) | PTGDR2MAPTGAASMN1; SMN2MEN1 | |
| SCHEMBL10686112 | 0.73 | MEN1 (0.68) | PTGDR2MAPTGAASMN1; SMN2MEN1 | |
| SCHEMBL1884723 | 0.73 | PTGDR2 (0.61) | PTGDR2MAPTGAASMN1; SMN2MEN1 | |
| SCHEMBL25804371 | 0.72 | GAA (0.56) | PTGDR2MAPTGAASMN1; SMN2MEN1 | |
| SCHEMBL4450568 | 0.71 | MEN1 (0.70) | PTGDR2MAPTGAASMN1; SMN2MEN1 | |
| SCHEMBL14433252 | 0.71 | MAPT (0.70) | PTGDR2MAPTGAASMN1; SMN2MEN1 | |
| SCHEMBL14433253 | 0.70 | PTGDR2 (0.65) | PTGDR2MAPTGAASMN1; SMN2MEN1 | |
| SCHEMBL10358643 | 0.70 | PTGDR2 (0.72) | PTGDR2MAPTGAASMN1; SMN2MEN1 | |
| SCHEMBL4604631 | 0.70 | TRPV4 (0.53) | PTGDR2MAPTGAASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101263130-A | 2-aniline-4-aryl substituted thiazole derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2008-09-10 | — | — | CN | claimed |
| EP-1926719-A2 | 2-ANILINE-4-ARYL SUBSTITUTED THIAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-06-04 | — | — | EP | claimed |
| WO-2007031440-A2 | 2-ANILINE-4-ARYL SUBSTITUTED THIAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-03-22 | — | — | WO | claimed |
| US-9388175-B2 | 2-aniline-4-aryl substituted thiazole derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2016-07-12 | — | — | US | disclosed |
| CN-101263130-B | 2-aniline-4-aryl substituted thiazole derivatives | JANSSEN PHARMACEUTICA NV | 2011-03-09 | — | — | CN | disclosed |
| CN-101263130-A | 2-aniline-4-aryl substituted thiazole derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2008-09-10 | — | — | CN | disclosed |
| EP-1926719-A2 | 2-ANILINE-4-ARYL SUBSTITUTED THIAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-06-04 | — | — | EP | disclosed |
| WO-2007031440-A2 | 2-ANILINE-4-ARYL SUBSTITUTED THIAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-03-22 | — | — | WO | disclosed |