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Glutamine

Glutamine

SCHEMBL4595490

CC(C)[C@H](N)C(=O)O.NC(=O)CC[C@H](N)C(=O)O.NC(=O)CC[C@H](N)C(=O)O.N[C@@H](CO)C(=O)O.N[C@@H](CS)C(=O)O.O=C(O)[C@@H]1CCCN1

nearest known ligand 0.38

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

SLC5A2

The experimentally established mechanism targets of Glutamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ ALOX15 P16050 1/20 0.38
▸ BLM P54132 1/20 0.38
▸ PMP22 Q01453 1/20 0.38
▸ KMT2A Q03164 1/20 0.38
▸ PTGS1 P23219 1/20 0.32
▸ SLC7A11 Q9UPY5 1/20 0.32
▸ SLC7A5 Q01650 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Glutamine SCHEMBL5665397 0.96 ALOX15 (0.41) ALOX15BLMPMP22KMT2APTGS1
Glutamine SCHEMBL6517171 0.96 ALOX15 (0.41) ALOX15BLMPMP22KMT2APTGS1
Glutamine SCHEMBL6371388 0.95 ALOX15 (0.40) ALOX15BLMPMP22KMT2APTGS1
Glutamine SCHEMBL18954801 0.95 ALOX15 (0.42) ALOX15BLMPMP22KMT2ASLC7A5
Glutamine SCHEMBL18954804 0.95 ALOX15 (0.42) ALOX15BLMPMP22KMT2ASLC7A5
Glutamine SCHEMBL5665046 0.94 ALOX15 (0.40) ALOX15BLMPMP22KMT2APTGS1
Glutamine SCHEMBL6377469 0.94 ALOX15 (0.40) ALOX15BLMPMP22KMT2APTGS1
Glutamine SCHEMBL6369944 0.93 ALOX15 (0.39) ALOX15BLMPMP22KMT2APTGS1
Glutamine SCHEMBL4398683 0.91 ALOX15 (0.39) ALOX15BLMPMP22KMT2ASLC7A5
Glutamine SCHEMBL4667538 0.91 KMT2A (0.46) ALOX15BLMPMP22KMT2ASLC7A5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8207133-B1 Peptides that down regulate the activity of plasma membrane transporters including sodium-D-glucose cotransporter SGLT1 JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG (DE) 2012-06-26 — — US disclosed
US-20120148673-A1 PEPTIDES THAT DOWN REGULATE THE ACTIVITY OF PLASMA MEMBRANE TRANSPORTERS INCLUDING SODIUM-D-GLUCOSE COTRANSPORTER SGLT1 JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG (DE) 2012-06-14 — — US disclosed
EP-1874330-A2 PEPTIDES THAT DOWN REGULATE THE ACTIVITY OF PLASMA MEMBRANE TRANSPORTERS INCLUDING SODIUM-D-GLUCOSE COTRANSPORTER SGLT1 Julius-Maximilians-Universität Würzburg (DE) 2008-01-09 — — EP disclosed
WO-2006105912-A2 PEPTIDES THAT DOWN REGULATE THE ACTIVITY OF PLASMA MEMBRANE TRANSPORTERS INCLUDING SODIUM-D-GLUCOSE COTRANSPORTER SGLT1 JULIUS-MAXIMILIANS-UNIVERSITÄT WÜRZBURG (DE) 2006-10-12 — — WO disclosed