Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Glutamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.35 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.33 |
| ▸ | GRM8 | O00222 | 1/20 | 0.31 |
| ▸ | GRM6 | O15303 | 1/20 | 0.31 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.31 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.31 |
| ▸ | GSR | P00390 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.31 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.31 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.31 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.31 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glutamine SCHEMBL6517171 | 1.00 | ALOX15 (0.41) | ALOX15BLMPMP22KMT2APTGS1 | |
| Glutamine SCHEMBL6371388 | 0.99 | ALOX15 (0.40) | ALOX15BLMPMP22KMT2APTGS1 | |
| Glutamine SCHEMBL6377469 | 0.98 | ALOX15 (0.40) | ALOX15BLMPMP22KMT2APTGS1 | |
| Glutamine SCHEMBL5665046 | 0.98 | ALOX15 (0.40) | ALOX15BLMPMP22KMT2APTGS1 | |
| Glutamine SCHEMBL6369944 | 0.97 | ALOX15 (0.39) | ALOX15BLMPMP22KMT2APTGS1 | |
| Glutamine SCHEMBL4595490 | 0.96 | ALOX15 (0.38) | ALOX15BLMPMP22KMT2APTGS1 | |
| Glutamine SCHEMBL27660739 | 0.94 | KMT2A (0.46) | ALOX15BLMPMP22KMT2ASLC7A5 | |
| Glutamine SCHEMBL4667538 | 0.94 | KMT2A (0.46) | ALOX15BLMPMP22KMT2ASLC7A5 | |
| Glutamine SCHEMBL5664624 | 0.94 | ALOX15 (0.36) | ALOX15BLMPMP22KMT2APTGS1 | |
| Glutamine SCHEMBL3047068 | 0.94 | ALOX15 (0.36) | ALOX15BLMPMP22KMT2APTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6962904-B1 | Elastin peptide analogs and uses thereof | CONNECTIVE TISSUE IMAGINEERING (US) | 2005-11-08 | — | — | US | claimed |
| EP-1392346-A4 | COMPOSITION AND METHOD FOR ENHANCING ELASTICITY OF TISSUE | CONNECTIVE TISSUE IMAGINEERING (US) | 2006-10-25 | — | — | EP | disclosed |
| US-6962904-B1 | Elastin peptide analogs and uses thereof | CONNECTIVE TISSUE IMAGINEERING (US) | 2005-11-08 | — | — | US | disclosed |
| US-6809075-B1 | Elastin peptide analogs and uses of same incombination with skin enhancing agents | CONNECTIVE TISSUE IMAGINEERING LLC | 2004-10-26 | — | — | US | disclosed |
| EP-1392346-A2 | COMPOSITION AND METHOD FOR ENHANCING ELASTICITY OF TISSUE | Connective Tissue Imagineering LLC (US) | 2004-03-03 | — | — | EP | disclosed |
| US-6506731-B1 | Peptide or peptide-like compound(s) of the present invention appear to aid the elasticity and/or turgor of the skin | CONNECTIVE TISSUE IMAGINEERING LLC | 2003-01-14 | — | — | US | disclosed |
| WO-2001091700-A2 | COMPOSITION AND METHOD FOR ENHANCING ELASTICITY OF TISSUE | CONNECTIVE TISSUE IMAGINEERING LLC (US) | 2001-12-06 | — | — | WO | disclosed |