Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 2/20 | 0.49 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | MME | P08473 | 1/20 | 0.39 |
| ▸ | ACE | P12821 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2532627 | 0.88 | TAAR1 (0.40) | AOC3RIPK1KDM4EMEN1KMT2A | |
| SCHEMBL16824912 | 0.86 | CPN1 (0.43) | AOC3RIPK1KDM4EMEN1KMT2A | |
| SCHEMBL1529543 | 0.84 | RIPK1 (0.54) | AOC3RIPK1KDM4EMEN1KMT2A | |
| SCHEMBL6050538 | 0.84 | RIPK1 (0.54) | AOC3RIPK1KDM4EMEN1KMT2A | |
| SCHEMBL6050419 | 0.84 | RIPK1 (0.54) | AOC3RIPK1KDM4EMEN1KMT2A | |
| SCHEMBL1529745 | 0.83 | GBA1 (0.39) | AOC3RIPK1KDM4ESLC6A2SLC6A4 | |
| SCHEMBL1529702 | 0.78 | MME (0.42) | RIPK1LMNAMMEACENPC1 | |
| SCHEMBL15311235 | 0.77 | AOC3 (0.54) | AOC3KDM4EMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL15311237 | 0.77 | AOC3 (0.54) | AOC3KDM4EMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL15311236 | 0.77 | AOC3 (0.54) | AOC3KDM4EMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874768-A2 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006113837-A2 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-26 | — | — | WO | disclosed |