Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15311235 | 1.00 | AOC3 (0.54) | AOC3KDM4EMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL15311236 | 1.00 | AOC3 (0.54) | AOC3KDM4EMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL15316178 | 0.82 | BACE1 (0.46) | AOC3KDM4EMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7996489 | 0.78 | LMNA (0.51) | KDM4EMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL4595769 | 0.77 | AOC3 (0.49) | AOC3KDM4EMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4732525 | 0.77 | AOC3 (0.47) | AOC3KDM4EMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4732524 | 0.77 | AOC3 (0.47) | AOC3KDM4EMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL11650819 | 0.76 | AOC3 (0.53) | AOC3KDM4EMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL11101163 | 0.75 | AOC3 (0.46) | AOC3KDM4EMEN1KMT2ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL11658826 | 0.75 | AOC3 (0.51) | AOC3KDM4EMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2657227-B1 | NOVEL SUBSTITUTED ISOQUINOLINE DERIVATIVE | WESTERN THERAPEUTICS INST INC D (JP) | 2016-04-27 | — | — | EP | disclosed |
| CN-103270024-B | Novel substituted isoquinoline derivative | WESTERN THERAPEUTICS INST INC | 2015-07-08 | — | — | CN | disclosed |
| US-8883792-B2 | Substituted isoquinoline derivative | D. WESTERN THERAPEUTICS INSTITUTE, INC. (JP) | 2014-11-11 | — | — | US | disclosed |
| EP-2657227-A1 | NOVEL SUBSTITUTED ISOQUINOLINE DERIVATIVE | D. Western Therapeutics Institute, Inc. (JP) | 2013-10-30 | — | — | EP | disclosed |
| US-20130274269-A1 | NOVEL SUBSTITUTED ISOQUINOLINE DERIVATIVE | D. WESTERN THERAPEUTICS INSTITUTE, INC. (JP) | 2013-10-17 | — | — | US | disclosed |
| CN-103270024-A | Novel substituted isoquinoline derivative | WESTERN THERAPEUTICS INST INC | 2013-08-28 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130274269-A1 | NOVEL SUBSTITUTED ISOQUINOLINE DERIVATIVE | SULT2A1, SULT1A1, SFPQ | AOC3 3588/4885KDM4E 3104/4885MEN1 3287/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.