Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.32 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4524066 | 0.90 | CYP1A2 (0.45) | ADRB2ADRB1DRD2CYP1A2CYP2C9 | |
| SCHEMBL4510996 | 0.82 | ADRB2 (0.46) | ADRB2ADRB1DRD2CYP1A2CYP2C9 | |
| SCHEMBL4514414 | 0.82 | CYP1A2 (0.44) | CYP1A2CYP2C9CYP2C19ALDH1A1HPGD | |
| SCHEMBL4514641 | 0.76 | ADRB2 (0.46) | ADRB2ADRB1DRD2CYP1A2CYP2C9 | |
| SCHEMBL4521520 | 0.76 | MTNR1A (0.45) | CYP1A2CYP2C9CYP2C19ALDH1A1CYP2D6 | |
| SCHEMBL586305 | 0.74 | CYP1A2 (0.52) | CYP1A2CYP2C9CYP2C19CYP2D6MTNR1A | |
| SCHEMBL14814398 | 0.73 | CNR1 (0.43) | ADRB2ADRB1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7785578 | 0.72 | CDYL (0.46) | ADRB2ADRB1DRD2CYP1A2CYP2C19 | |
| SCHEMBL4526077 | 0.72 | CNR1 (0.43) | ADRB2ADRB1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL3113301 | 0.70 | CYP1A2 (0.44) | CYP1A2CYP2C9CYP2C19CYP2D6MTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937656-A1 | 7-(2-AMINO-1-HYDROXY-ETHYL)-4-HYDROXYBENZOTHIAZOL-2(3H)-ONE-DERIVATIVES AS BETA 2 ADRENOCEPTOR AGONISTS | AstraZeneca AB (SE) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007027134-A1 | 7-(2-AMINO-1-HYDROXY-ETHYL)-4-HYDROXYBENZOTHIAZOL-2(3H)-ONE-DERIVATIVES AS β2 ADRENOCEPTOR AGONISTS | ASTRAZENECA AB (SE) | 2007-03-08 | — | — | WO | disclosed |