Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | ACE | P12821 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4073210 | 0.80 | CYP3A4 (0.46) | CYP2C19LMNAMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL1273081 | 0.80 | CYP3A4 (0.46) | CYP2C19LMNAMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL4596217 | 0.78 | NPC1 (0.45) | CYP2C19MAPTKDM4EALDH1A1NPC1 | |
| SCHEMBL4658500 | 0.74 | KDM4E (0.49) | LMNAMAPTKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL9788167 | 0.73 | CYP1A2 (0.41) | CYP2C19LMNAALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL8233122 | 0.73 | CYP2C19 (0.45) | CYP2C19LMNAMAPTALDH1A1HPGD | |
| SCHEMBL31489064 | 0.72 | CYP1A2 (0.46) | CYP2C19LMNAALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL9171687 | 0.72 | CYP2C19 (0.50) | CYP2C19LMNAALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL13696274 | 0.71 | CYP2C19 (0.46) | CYP2C19LMNAALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL8233124 | 0.71 | PPARG (0.45) | CYP2C19LMNAMAPTALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874768-A2 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006113837-A2 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-26 | — | — | WO | disclosed |