Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | PTPRB | P23467 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1273081 | 0.80 | CYP3A4 (0.46) | ALDH1A1TSHRSMN1; SMN2MEN1KMT2A | |
| SCHEMBL4073210 | 0.80 | CYP3A4 (0.46) | ALDH1A1TSHRSMN1; SMN2MEN1KMT2A | |
| SCHEMBL5221235 | 0.80 | KDM4E (0.49) | KDM4EPOLBALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL4596217 | 0.78 | NPC1 (0.45) | KDM4EPOLBALDH1A1MEN1KMT2A | |
| SCHEMBL3725498 | 0.78 | KDM4E (0.51) | KDM4EALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL31397663 | 0.75 | KDM4E (0.51) | KDM4EPOLBALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL4595848 | 0.74 | CYP2C19 (0.41) | KDM4EALDH1A1SMN1; SMN2MAPTPPARA | |
| SCHEMBL3511351 | 0.74 | KDM4E (0.46) | KDM4EPOLBALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL3957626 | 0.73 | KDM4E (0.62) | KDM4EPOLBALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL1692813 | 0.73 | KDM4E (0.31) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720855-A4 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORP (US) | 2008-12-17 | — | — | EP | disclosed |
| EP-1720855-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2006-11-15 | — | — | EP | disclosed |
| WO-2005085227-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2005-09-15 | — | — | WO | disclosed |