Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1273081 | 1.00 | CYP3A4 (0.46) | CYP3A4ALDH1A1CYP2C19CYP2C9RECQL | |
| SCHEMBL3725498 | 0.87 | KDM4E (0.51) | ALDH1A1NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL4594149 | 0.86 | RAB9A (0.43) | ALDH1A1MAPK1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4773478 | 0.86 | LMNA (0.41) | CYP3A4ALDH1A1CYP2C19CYP2C9MMP8 | |
| SCHEMBL4583207 | 0.85 | CYP3A4 (0.50) | CYP3A4ALDH1A1CYP2C19CYP2C9RECQL | |
| SCHEMBL4379160 | 0.84 | FDPS (0.46) | CYP3A4ALDH1A1CYP2C19CYP2C9RECQL | |
| SCHEMBL1539491 | 0.84 | VNN1 (0.42) | RAB9ATAAR1MEN1KMT2ARIPK1 | |
| SCHEMBL3960044 | 0.84 | RIPK1 (0.41) | ALDH1A1NPC1RAB9ASMN1; SMN2TAAR1 | |
| SCHEMBL16757585 | 0.84 | CYP2C9 (0.44) | CYP3A4ALDH1A1CYP2C19CYP2C9RECQL | |
| SCHEMBL4596217 | 0.84 | NPC1 (0.45) | CYP3A4ALDH1A1CYP2C19CYP2C9CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1653961-A4 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORP (US) | 2009-04-01 | — | — | EP | disclosed |
| EP-1874768-A2 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006113837-A2 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-26 | — | — | WO | disclosed |
| EP-1653961-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2006-05-10 | — | — | EP | disclosed |
| WO-2005011700-A1 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2005-02-10 | — | — | WO | disclosed |